• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    MEDICAL DEVICE FOR TREATING HARD TISSUE AND OSTEOTOMIC MEDICAL DEVICE FOR TREATING A VERTEBRAL BODY Methods and devices that move bone or other rigid tissue to create a cavity in the tissue. In which such methods and devices rely on a driving mechanism to provide movement of the device to form a profile that improves tissue displacement. These methods and devices also allow you to create a path or cavity in the bone for insertion of bone cement or other fill to treat a fracture or other condition in the bone. Features related to the methods and devices described here can be applied to any region of bone or rigid tissue where the tissue or bone is displaced to define a hole or cavity rather than being extracted from the body as during the drilling procedure or ablation.
    公开号:BR112012027708B1
    申请号:R112012027708-1
    申请日:2011-04-29
    公开日:2021-03-09
    发明作者:Aaron GERMAIN；John H. Shadduck；Csaba Truckai
    申请人:Dfine, Inc；
    IPC主号:
    专利说明:

    FIELD OF THE INVENTION
    [001] This invention relates to medical instruments and systems to create a path or cavity in the vertebral bone to receive bone cement to treat a vertebral compression fracture. Aspects related to the methods and devices described here can be applied to any region of bone or rigid tissue where the tissue or bone is displaced to define a hole or cavity instead of being extracted from the body as during the drilling or ablation procedure . In addition, the present invention also discloses methods and devices for ablating or coagulating tissues, including, but not limited to, ablating tumor tissue in the vertebral and / or cortical bone. SUMMARY OF THE INVENTION
    [002] The methods and devices described here refer to the improved creation of a cavity within bone or other rigid tissue in which the cavity is created by displacing the tissue. In a first example, a method according to the present disclosure includes treating a vertebral body or other bone structure. In a variation, the method includes providing an elongated tool having a sharp tip configured to penetrate the vertebral bone, the tool having an axis extending from a proximal end to a working end thereof, where the working end comprises at least at least one first sleeve concentrically located within a second sleeve and a third sleeve concentrated concentrically around the second sleeve, each sleeve comprising a series of grooves or notches to limit the deflection of the working end to a first curved configuration in a plane unique and in which the respective series of grooves or notches are radially established in each sleeve; advance the working end through the vertebral bone; causing the working end to move from a linear configuration to a curved configuration by translating the first sleeve in relation to the second sleeve in an axial direction; and moving the working end in the curved configuration within the bone to create a cavity in it. The translation of the first sleeve in relation to the second sleeve may include moving either the sleeve or both sleeves in an axial direction. Additional variations include moving one or both sleeves in a rotational direction to produce the relative axial displacement between the sleeves.
    [003] In a further variation, the present device includes medical osteotome devices that can treat a rigid tissue (for example, in a vertebral body) by mechanically displacing the rigid tissue and / or applying therapeutic energy to ablate or coagulate the tissue. For example, such a variation includes an osteotome-type device that is coupled to a power supply and further includes a cable having a drive part and a connector for electrically coupling the osteotome device to the power supply; a rod comprising a first sleeve located concentrically within a second sleeve, the rod having a distal part comprising a working end capable of moving between a linear configuration and an articulated configuration in which the articulated configuration is limited to a single plane, and wherein each sleeve comprises a series of grooves or notches to limit the deflection of the working end to the hinged configuration, where the respective series of grooves or notches are radially established in the adjacent sleeves, where a first conductive part of the stem is electrically attachable to a first pole of the power supply; a sharp point located at a distal end of the first sleeve of the working end, the sharp point adapted to penetrate the bone inside the vertebral body, in which the distal tip is attachable to a second pole of the energy supply, so that when activated , the current flows between a part of the distal tip and the stem; a non-conductive layer electrically insulating the first sleeve from the first conductive part; and in which the stem and the sharp point have sufficient column strength so that the application of an impact force on the handle causes the distal part of the stem and the distal tip to mechanically displace the rigid tissue. The power supply can be attached to the outer sleeve (or the second or third sleeves discussed here).
    [004] Other variations of the method disclosed here may include applying energy between electrodes in the tissue ablation device (eg, tumor) or to perform other electrosurgical or mapping procedures within the tissue. In such an example for treating a vertebral body, the method may include providing an elongated tool having a sharp tip configured to penetrate the vertebral bone, the tool having an axis extending from a proximal end to a working end thereof, where the working end comprises at least one first sleeve located concentrically within a second sleeve, wherein each sleeve comprises a series of grooves or notches to limit the deflection of the working end to a first curved configuration in a single plane and where the the respective series of grooves or notches is radially established in the adjacent sleeves, in which a first conductive part of the first sleeve is electrically coupled to a first pole of an energy supply; advance the working end through the vertebral bone; causing the working end to move from a linear configuration to a curved configuration by translating the first sleeve in relation to the second sleeve in an axial direction; and applying the energy between the first conductive part and a return electrode electrically coupled to a second pole of the energy supply to ablate or coagulate a region within the vertebral body.
    [005] In method variations, moving the working end from the linear to the curved configuration includes moving the working end to move through a plurality of curved configurations.
    [006] In a further variation, causing the working end to move from a linear configuration to the curved configuration comprises driving a cable mechanism to move the working end from the linear configuration to the curved configuration. The cable mechanism can be moved axially and / or rotationally as described here.
    [007] In a variation, the activation of the cable mechanism causes the working end to move to the first curved configuration without twisting the third sleeve.
    [008] In additional variations, the working end of the osteotome or tool is influenced by spring to assume the linear configuration.
    [009] The working end can move from the linear configuration to the curved configuration by applying a driving force or impact to the elongated tool where penetration into the cortical bone moves the working end from the linear configuration to the curved configuration. For example, as an impact or blow force is applied to the working end, the interaction of the sharp tip against the bone causes the working end to assume an articulated and / or curved configuration. Where another axial movement of the tool causes bone compression and cavity creation.
    [010] The method may also include the use of one or more cannulas to introduce the tool into the target region. Such a cannula can keep the tool in a straight or linear configuration until the tool advances out of the cannula or until the cannula is removed from the top of the tool.
    [011] As described here, after the cavity is created, the method may also include the insertion of a filling material or other substance in the cavity. The filling material can be administered through the tool or through a separate cannula or catheter.
    [012] This disclosure also includes variations of the devices for creating a cavity within the bone or rigid tissue. Such variations include devices for treating a vertebral body or other such structure. In a variation, a device includes a cable having a drive part; a rod comprising a first sleeve concentrically located within a second sleeve and a third sleeve concentrated concentrically around the second sleeve, the rod having a distal part comprising a working end capable of moving between a linear configuration and an articulated configuration in which the second hinged configuration is limited to a single plane, and where each sleeve comprises a series of grooves or notches to limit the deflection of the working end to the hinged configuration, where the respective series of grooves or notches is radially established in each mango; and a sharp point located at a distal tip of the working end, the sharp point adapted to penetrate the vertebral bone into the vertebral body.
    [013] In a variation, the devices described here may include a configuration in which the first sleeve is attached to the second sleeve at the working end so that the proximal movement of the first sleeve causes the working end to assume the hinged configuration. The sleeves can be attached anywhere along their length using a mechanical fastening means (for example, a pin or other fastening means), an adhesive, or one or more welding points. In some variations, the fixation of the sleeves occurs at the working end so that the movement of the inner sleeve or first sleeve causes the working end to assume the curved configuration. In some cases, the third sleeve may be affixed outside the working end as long as the first and second sleeve are pivoted, the third sleeve is still pivoted.
    [014] The devices described here can optionally include a force limiting assembly coupled between the drive part and the first sleeve so that after reaching a limit force, the drive part disengages the first sleeve. In one variation, the force limiting mechanism is adapted to limit the force applied to the bone when moving the working end from the first configuration towards the second configuration.
    [015] In additional variations, devices for creating cavities in bone or rigid tissue may include one or more spring elements that extend through the first sleeve, where the spring element is affixed to the stem (in or around the first , second or third sleeve). Such spring elements cause the working end to assume a linear configuration in a relaxed state.
    [016] In additional variations, a device may include an outer sleeve or third sleeve in which the grooves or notches (which allow deflection) are located on an outer surface of the third sleeve. The outer surface is typically the outwardly facing surface from a direction of the curved configuration. This configuration allows an internal surface (the surface located inside the curved part) to be smooth. As a result, if the device is removed through tissue or a cannula or other introducer, the smooth surface inside the curve minimizes the chance that the device will get caught in the opening of the cannula or any other structure.
    [017] Variations of the device may include one or more lumens that extend along the rod and the working end. These lumens can exit at a distal end of the device or through a side opening in a wall of the device. The lumen may include a surface comprising a lubricated polymeric material. For example, the material can comprise any biocompatible material having low frictional properties (for example, TEFLON®, a polytetrafluoroethylene (PTFE), FEP (fluoroethylenepropylene), polyethylene, polyamide, ECTFE (Ethylene Chlorotrifluoro-ethylene), ETFE, PVDF, chloride polyvinyl and silicone).
    [018] As described here, devices can include any number of configurations to prevent rotation between adjacent sleeves, but allow axial movement between sleeves. For example, the sleeves can be mechanically coupled through a pin / groove or key / keyway configuration. In an additional variation, the sleeves may be non-circular to prevent rotation.
    [019] In a further variation, the disclosure includes several kits comprising the device described here, as well as a filler material (for example, bone cement or other bone filler material).
    [020] The variations of the access device and procedures described above include combinations of aspects of the various achievements or combination of the achievements themselves whenever possible.
    [021] The methods, devices and systems described here can be combined with the patent applications commonly assigned below and provisional applications, all of which are incorporated here by reference: Application Number 61 / 194,766, filed on 30 September 2008; Application Number 61 / 104,380, filed on October 10, 2008; Application Number 61 / 322,281, filed on April 8, 2010; Order Number 12 / 571,174 filed on September 30, 2009; PCT application number PCT / US2009 / 059113 filed on 09/30/2009; Application Number 12 / 578,455 filed on October 13, 2009. BRIEF DESCRIPTION OF THE DRAWINGS
    [022] FIG. 1 is a plan view of an osteotome of the invention.
    [023] FIG. 2 is a side view of the osteotome of FIG. 1.
    [024] FIG. 3 is a cross-sectional view of the osteotome of FIG. 1.
    [025] FIG. 4 is an enlarged sectional view of the osteotome cable of FIG. 1.
    [026] FIG. 5 is an enlarged sectional view of the working end of the osteotome of FIG. 1.
    [027] FIG. 6A is a sectional view of the working end of FIG. 5 in one. linear configuration.
    [028] FIG. 6B is a sectional view of the working end of FIG. 5 in a curved configuration.
    [029] FIGS. 7A-7C are schematic sectional views of a method of using the osteotome of FIG. 1.
    [030] FIG. 8 is another embodiment of an osteotome working end.
    [031] FIG. 9 is another embodiment of an osteotome working end.
    [032] FIG. 10 is another variation of an osteotome with an outer sleeve.
    [033] FIG. 11 is a cross-sectional view of the working end of the osteotome of FIG. 10.
    [034] FIG. 12A is a sectional view of another embodiment of the working end, taken along line 12A-12A of FIG. 11.
    [035] FIGS. 12B and 12C illustrate additional variations in preventing rotation between adjacent sleeves.
    [036] FIG. 13 is a sectional view of another embodiment of the working end similar to that of FIG. 11.
    [037] FIG. 14 is a perspective cross-sectional view of the working end of FIG. 13.
    [038] FIG. 15 illustrates a variation of an osteotome as described here having electrodes on one end of the device and another electrode on the nail.
    [039] FIG. 16 illustrates an osteotome device as shown in FIG. 15 after being advanced in the body and in which the current passes between the electrodes.
    [040] FIG. 17 illustrates a variation of a device as described here further including a connector for providing power at the working end of the device.
    [041] FIGS. 18A and 18B illustrate a device having a sharp point as disclosed here in which the sharp point is advancing from the distal end of the rod.
    [042] FIG. 19 shows a cross-sectional view of the device illustrated in FIG. 18B and also illustrates the temperature sensing elements located on the device.
    [043] FIG. 20 shows a variation of a device in which the inner sleeve is extended from the device and in which the current is applied between the extended part of the inner sleeve and the stem to treat the fabric.
    [044] FIG. 21 illustrates a variation of a device as described here, further including an extensible helical electrode charged by the working end of the device.
    [045] FIGS. 22A and 22B illustrate the device of FIG. 21 with the helical electrode in an unstretched position and an extended position.
    [046] FIGS. 23A and 23B illustrate comparison tests between a first osteotome without a helical electrode and a second osteotome 600 with a helical electrode as in FIG. 22B.
    [047] FIG. 24 illustrates the working end of the device of FIG. 21 in a vertebral body with the helical electrode delivering RF energy to the tissue for ablation or other treatments.
    [048] FIG. 25 illustrates an alternative hinge ablation device with the working end including electrode surfaces of opposite polarity in an external radius of the hinged working end.
    [049] FIG. 26 represents the hinged working end of FIG. 25 in a vertebral body delivering RF energy to the tissue in which an isolated surface directs the energy away from the spinal canal.
    [050] FIG. 27 illustrates an alternative hinge device with the working end including a plurality of extensible electrodes extending from an external radius of the hinged working end.
    [051] FIG. 28 represents the hinged working end of FIG. 27 in a vertebral body applying RF energy to the tissue in which the plurality of extended electrodes directs the energy away from the vertebral canal.
    [052] FIG. 29 illustrates an alternative hinge ablation device with the working end including electrode surfaces of opposite polarity and a source of an insulating or gel flow medium attachable to a lumen in the device.
    [053] FIG. 30 represents the hinged working end of FIG. 29 in a vertebral body by applying energy to the tissue in which an insulating gel directs the energy away from the spinal canal. DETAILED DESCRIPTION
    [054] With reference to FIGS. 1-5, an apparatus or osteotome 100 is shown that is configured to access the interior of a vertebral body and to create a pathway in the porous vertebral bone to receive bone cement. In one embodiment, the apparatus is configured with an extension part or member 105 to introduce through a pedicle and in which a working end 110 of the extension member can be progressively actuated to bend a selected degree and / or rotate to create a curved pathway and cavity towards the midline of the vertebral body. The device can be removed and the bone filling material can be introduced through a bone cement injection cannula. Alternatively, the apparatus 100 itself can be used as a cement injector with the subsequent injection of cement through a lumen 112 of the apparatus.
    [055] In one embodiment, the apparatus 100 comprises a cable 115 which is coupled to a proximal end of the extension member 105. The extension member 105 comprises an assembly of the first (outer) sleeve 120 and a second (inner) sleeve 122 , with the first sleeve 120 having a proximal end 124 and a distal end 126. The second sleeve 122 has a proximal end 134 and a distal end 136. Extension member 105 is coupled to cable 115, as will be described below, to allow a doctor to drive the extension member 105 into the bone while simultaneously driving the working end 110 and a driven or curved configuration (see FIG. 6). The cable 115 may be made of a polymer, metal or any other material suitable to withstand impact or impact forces used to drive the assembly into the bone (for example, through the use of a hammer or similar device on the cable 115). The inner and outer sleeves are made of a suitable metal alloy, such as stainless steel or NiTi. The wall thickness of the inner or outer sleeves can vary from about 0.005 ”to 0.010” with the outer diameter of the outer sleeve varying from about 2.5 mm to 5.0 mm.
    [056] With reference to FIGS. 1, 3, and 4, cable 115 comprises both a first control part 140 and a second driver part indicated at 142. Control part 140 is coupled to the first sleeve 120 as will be described below. The driver part 142 is operationally coupled to the second sleeve 122 as will be described below. The driver part 142 is rotatable relative to the control part 140 and one or more flexible plastic tabs 145 of the control part 140 are configured to fit the grooves 146 on the rotatable driver part 142 to provide tactile indication and temporary locking of the cable parts 140 and 142 in a certain degree of rotation. The flexible tabs 145 in this way fit and detach from the grooves 146 to allow adjustment (rotation and locking) of the parts of the cable and the respective sleeve attached to it.
    [057] The grooves or indentations in any of the sleeves can comprise a uniform width along the length of the working end or can comprise a variant width. Alternatively, the width can be selected in certain areas to make a particular curved profile. In another variation, the width can increase or decrease along the working end to create a curve having a varying radius. Clearly, it is understood that any number of variations are within the scope of this disclosure.
    [058] FIG. 4 is a sectional view of the cable showing a mechanism for driving the second inner sleeve 122 in relation to the first outer sleeve 120. The driver part 142 of the cable 115 is configured with a quick-fit helical channel indicated at 150 that cooperates with a filament projecting 149 from the control part 140 of the cable. In this way, it can be understood that the rotation of the drive part 142 will move this part to the position indicated at 150 (phantom view). In one embodiment, when the driver part 142 is rotated by a selected amount from about 45 ° to 720 °, or from about 90 ° to 360 °, the inner sleeve 122 is raised in relation to the part control 140 and outer sleeve 120 to drive working end 110. As can be seen in FIG. 4 the driver part 142 engages the flange 152 which is welded to the proximal end 132 of the inner sleeve 122. The flange 152 is raised by means of a ball support assembly 154 arranged between the flange 152 and the metal support surface 155 inserted in the control part 140 of the cable. In this way, the rotation of the driver 142 can raise the inner sleeve 122 without creating torque on the inner sleeve.
    [059] Now with reference to FIGS. 5, 6A and 6B, it can be seen that the working end 110 of the extension member 105 is hinged by cooperating the grooved parts of the distal parts of the outer sleeve 120 and the inner sleeve 122 which are both thus capable of bending in a radius substantially tight. The outer sleeve 120 has a plurality of grooves or notches 162 therein which can be any grooves that are perpendicular or angled with respect to the axis of the sleeve. The inner sleeve 122 has a plurality of grooves or notches indicated at 164 that can be on the opposite side of the assembly in relation to the grooves 162 in the outer sleeve 120. The outer and inner sleeves are welded together in the distal region indicated in the weld 160. You can , in this way, it will be understood that when the inner sleeve 122 is translated in the proximal direction, the outer sleeve will be flexed as shown in FIG. 6B. It can be understood that by rotating the portion of the trigger cable 142 a selected amount, the working end can be hinged to a selected degree.
    [060] FIGS. 4, 5, 6A and 6B illustrate yet another element of the apparatus comprising a flexible straight wire member 170 with a proximal end 171 and flange 172 which engages the proximal side of the flange 152 of the inner sleeve 122. At least the distal part 174 of the straight wire member 170 is welded to the inner sleeve at weld 175. This straight wire member thus provides a safety feature for retaining the working end if the inner sleeve fails in one of the grooves 164.
    [061] Another safety feature of the device comprises a torque limiter and release system that allows the entire cable assembly 115 to rotate freely - for example, if the working end 110 is hinged, as in FIG. 6B, when the doctor rotates the handle and when the working end is attached to the strong porous bone. With reference to FIG. 4, the control part 142 of the cable 115 engages a collar 180 that is attached to a proximal end 124 of the outer sleeve 120. The collar 180 further comprises grooves 185 that are radially spaced around the collar and are fitted through a member of ball 186 which is driven by a spring 188 in grooves 185. At a selected force, for example, torque varying by more than about 0.5 inch * lbs, but less than about 7.5 inch * 5 lbs, 0 inch * lbs or 2.5 inch * lbs, cable rotation 115 exceeds the predetermined limit. When the torque limiting assembly is in its locked position, ball support 186 is forced into one of the grooves 185 on collar 180. When too much torque is provided for the cable and outer sleeve, ball support 186 disengages from the groove 185 allowing collar 180 to turn, and then snap back into the next groove, releasing anywhere from 0.5 inch * lbs to 7.5 inch * lbs of torque.
    [062] With reference to FIGS. 6A and 6B, it can be understood that the inner sleeve 122 is weakened on one side in its distal part in order to allow the inner sleeve 122 to bend in both directions, but is limited by the location of the grooves in the outer sleeve 120. A The curvature of any articulated configuration is controlled by the spacing of the grooves as well as the distance between each peak of the groove. The inner sleeve 122 also has a chamfered tip to enter through the cortical bone of a vertebral body. Either the inner sleeve or the outer sleeve can form the distal tip.
    [063] With reference to FIGS. 7A-7C, in a variation of use of the device, a physician pierces or otherwise conducts a stylus 200 and an introducing sleeve 205 into a vertebral body 206 typically until the tip of stylus 208 is within the anterior 1/3 of the body vertebral towards the cortical bone 210 (FIG. 7A). After that, the stylus 200 is removed and the sleeve 205 is moved closely (FIG. 7B). As can be seen in FIG. 7B, the tool or osteotome 100 is inserted through the introducer sleeve 205 and articulated in a series of steps as described above. The working end 110 can be pivoted intermittently while applying driving forces and optionally rotational forces to the handle 115 to advance the working end through the porous bone 212 to create a path or cavity 215. The tool is then pushed to further drive the end working 110 to, towards or before the midline of the vertebra. The physician may alternatively articulate the working end 110, and further drive and rotate the working end until imaging shows that the working end 100 has created a cavity 215 of an optimal configuration. After that, as shown in FIG. 7C, the doctor reverses the sequence and progressively straightens the working end 110 as the extension member is removed from the vertebral body 206. After that, the doctor can insert a bone cement injector 220 into the path or cavity 215 created by osteotome 100. FIG. 7C illustrates a bone cement 222, for example, a PMMA cement, being injected from a bone cement source 225.
    [064] In another embodiment (not shown), the apparatus 100 may have a cable 115 with a Luer fitting for coupling a bone cement syringe and the bone cement may be injected through the lumen 112 of the apparatus. In such an embodiment of FIG. 9, the lumen may have a lubricated surface layer or polymeric coating 250 to ensure less resistance to bone cement as it flows along the lumen. In one embodiment, the surface or coating 250 may be a fluorinated polymer such as TEFLON® or polytetrafluoroethylene (PTFE). Other suitable fluoro polymer resins can be used such as FEP and PFA. Other materials can also be used such as FEP (fluorinated ethylene propylene), ECTFE (ethylene chlorochlorofluoroethylene), ETFE, Polyethylene, Polyamide, PVDF, Polyvinyl chloride and silicone. The scope of the invention may include providing a polymeric material having a static coefficient of friction of less than 0.5, less than 0.2 or less than 0.1.
    [065] FIG. 9 also shows the extension member or rod 105 can be configured with an external flexible sleeve indicated at 255. The flexible sleeve can be any commonly known bio-compatible material, for example, the sleeve can comprise any of the materials described in the previous paragraph.
    [066] As can also be seen in FIG. 9, in a variation of the device 100, the working end 110 can be configured to deflect over a length indicated at 260 in a substantially light curve. The degree of articulation of the working end 100 can be at least 45 °, 90 °, 135 ° or at least 180 ° as indicated in 265 (FIG. 9). In further variations, the grooves of the outer 120 and inner 120 sleeves can be varied to produce a device having a radius of curvature that varies between the length 260 of the device 100.
    [067] In another embodiment of the invention, the inner sleeve can be loaded by the spring in relation to the outer sleeve, in order to allow the working end to straighten below a selected level of force when pulled in a linear direction. This feature allows the clinician to remove the vertebral body assembly partially or completely without turning the drive portion 142 of the cable 115 further. In some variations, the force limiter can be provided to allow less than about 10 inch * lbs of force to be applied to the bone.
    [068] In another embodiment shown in FIG. 8, the working end 110 is configured with a tip 240 that deflects to the position indicated at 240 ’when directed to the bone. The tip 240 is coupled to the sleeve assembly through the resilient member 242, for example, a flexible metal such as stainless steel or NiTi. It has been found that flexing the tip 240 causes its distal surface area to fit with the porous bone which can assist in the deflection of the working end 110 as it is deepened into the bone.
    [069] In another embodiment of the invention (not shown), the trigger cable may include a secondary (or optional) mechanism for driving the working end. The mechanism would include a hammer member with a rack so that each blow of the hammer would advance the assembly and progressively drive the working end in a curved configuration. A rack mechanism as known in the art would maintain the assembly in each of a plurality of articulated configurations. A release would be provided to allow the release of the rack to provide the straightness of the extension member 105 for removal from the vertebral body.
    [070] FIGS. 10 and 11 illustrate another variation of a bone treatment device 400 with a cable 402 and extension member 405 extending to the working end 410 having a construction similar to those of FIGS. 1 to 6B. The device 400 operates as previously described with the first grooved sleeve (external) 120 and the second grooved sleeve (internal) 122 cooperates. However, the variation shown in FIGS. 10 and 11 also includes a third sleeve with concentric groove 420, external to the first 120 and the second 122 sleeves. The grooves or notches in the sleeve 420 at the working end 410 allow the deflection of the sleeve as indicated at 265 in FIG. 11.
    [071] FIG. 10 also illustrates treatment device 400 as including a luer fitting 412 that allows device 402 to be coupled to a source of a filler material (e.g., a bone filler or bone cement material). The luer can be removable from the cable 402 to allow an impact force to be applied to the cable as described above. In addition, the luer fitting 402 can be located on the cable drive part, the fixed part of the cable or even along the sleeve. In any case, variations of the device 400 allow the filling material to be coupled with a lumen extending along the sleeves (or between adjacent sleeves) to deposit the filling material on the working end 410. As shown by arrows 416, the filling material can be deposited through a distal end of the sleeves (where the sharp tip is solid) or it can be deposited through openings in a side wall of the sleeves. Clearly, variations of this configuration are within the scope known to those skilled in the art.
    [072] In some variations, the third grooved sleeve 420 is configured with its smooth (non-grooved) surface 424 disposed internally on the articulated working end (FIG. 11) so that a solid surface is formed inside the part curved working end 410. The smooth surface 424 allows removal of the device 110 in a cannula or introducer 205 without creating a risk that the grooves or notches will become trapped in a cannula 205 (see, for example, FIG. 7B) .
    [073] As shown in FIGS. 10-11, the third (outermost) sleeve 420 may extend from an intermediate location on the extension member 405 to a distal end of the working end 410. However, variations of the device include the third sleeve 420 extending for cable 402. However, the third sleeve 420 is not typically coupled to the cable 402 so that any rotational force or torque generated by the cable 402 is not directly transmitted to the third sleeve 420.
    [074] In a variation, the third sleeve 420 is coupled to the second sleeve 120 in only one axial location. In the illustrated example shown in FIG. 11, the third sleeve 420 is attached to the second sleeve 420 by welds 428 at the distal end of the working end 410. However, welds or other fastening means (e.g., a pin, wrench / keyway, protrusion etc.). ) can be located in a middle part of sleeve 420. Sleeve 420 can be made of any bio-compatible material. For example, in one variation, the third sleeve is made from a stainless steel material with a diameter of 3.0 mm with a wall thickness of 0.007 ”. The first, second and third sleeves are dimensioned to have dimensions to allow a sliding fit between the sleeves.
    [075] FIG. 12A is a sectional view of extension member 405 of another variation, similar to that shown in FIGS. 10-11. However, the variation represented by FIG. 12A comprises a non-rounded configuration of the concentric sliding sleeves (double or triple sleeve devices). This configuration limits or prevents rotation between the sleeves and allows the physician to apply greater forces to the bone to create a cavity. While FIG. 12A illustrates an oval configuration, any non-rounded shape is within the scope of this disclosure. For example, the cross-sectional shape may comprise a square, polygonal or other radially switched configuration as shown in FIGS. 12B and 12C. As shown in FIG. 12C the sleeves may include a key 407 and a receiving key path 409 to prevent rotation, but allow relative or axial sliding of the sleeves. The key comprises any member or protrusion that slides within a receiving key path. In addition, the key may comprise a pin or any raised protrusion inside or outside of a respective sleeve. In this illustration, only the first 122 and the second 122 sleeves are illustrated. However, any of the sleeves can be configured with the key / keyway. Preventing rotation between the sleeves improves the ability to apply force to the bone at the hinged working end.
    [076] FIGS. 13-14 illustrate another variation of a working end 410 of an osteotome device. In this variation, the working end 410 includes one or more flat spring elements 450, 460a, 460b, 460c, 460d, which prevents the relative rotation of the joint sleeves thus allowing greater rotational forces to be applied to the porous bone from an articulated working end. The spring elements further drive the working end assembly in a linear configuration. To articulate the sleeves, a rotational force is applied to the cable as described above, once this rotational force is removed, the spring elements propel the working end in a linear configuration. As shown in FIG. 13, one or more spring elements may extend along the sleeves to affix to a cable to prevent rotation. In addition, the distal end 454 of the flat spring element 450 is fixed to the sleeve assembly by the weld 455. Thus, the spring element is fixed at each end to prevent its rotation. Alternative variations include one or more spring elements being attached to the inner sleeve assembly in a mid-section of the sleeve.
    [077] As shown in FIGS. 13-14, osteotome variations can include any number of spring elements 460a-460d. These additional spring elements 460a-460d can be welded to or at a proximal or distal end thereof to an adjacent element or a sleeve to allow the element to function as a leaf spring.
    [078] In a further variation, the osteotome device may include one or more electrodes 310, 312 as shown in FIG. 15. In this particular example, device 300 includes spaced independent electrodes having opposite polarity to function in a bipolar manner. However, the device may include a monopolar configuration. In addition, one or more electrodes can be coupled to individual channels of a power supply so that the electrodes can be energized as needed. Any variation of the device described above can be configured with one or more electrodes as described here.
    [079] Fig. 16 illustrates an osteotome device 300 after being advanced into the body as discussed above. As shown by lines 315 representing the current flow between the electrodes, when necessary, the physician can conduct RF current between electrodes 310 and 312 to apply coagulative or ablative energy within the bone structure of the vertebral body (or other rigid tissue). While Fig. 16 illustrates the RF current flow 315 between electrodes 310 and 312, variations in the device may include a number of electrodes throughout the device to apply the appropriate therapeutic energy. In addition, an electrode can be spaced from the end of the osteotome instead of being placed on the sharp tip as shown by electrode 310. In some variations, the power supply is coupled to the inner sharp tip or other working end of the first sleeve . In these variations with only two sleeves, the second pole of the power supply is coupled with the second sleeve (which is the outside of the device) to form a return electrode. However, in these variations having three sleeves, the energy supply can alternatively be coupled with the third outer sleeve. In other additional variations, the second and third sleeves can both function as return electrodes. However, in these devices that are monopolar, the return electrode will be placed outside the body over a large area of the skin.
    [080] Figs. 17 to 20 illustrate another variation of an articulation probe or osteotome device 500. In this variation, device 500 includes a working end 505 that carries one or more RF electrodes that can be used to conduct current through it. In this way, the device can be used to detect tissue impedance, locate nerves, or simply apply electrosurgical energy to the tissue to coagulate or ablate the tissue. In potential use, the device 500 can apply ablative energy to a tumor or other tissue within the vertebra as well as create a cavity.
    [081] FIGS. 17, 18A, 18B and 19 illustrate a variation of the device 500 as having a part of the cable 506 coupled to a stem assembly 510 that extends along the axis 512 to the hinge working end 505. The hinge working end 505 can be actionable as described above. In addition, FIG. 17 shows that the cable component 514a can be rotated with respect to the cable component 514b to cause relative axial movement between the first outer sleeve 520 and the second inner sleeve 522 (FIG. 19) to cause the grooved working ends of the sleeve assembly to articulate as described above. The working end 505 of FIG. 19 shows two sleeves 520 and 522 that are operable to articulate the working end, but it should be noted that a third external articulation sleeve can be added as shown above. In one variation, the pivot working end can pivot 90 ° by rotating the cable component 514a between% turn and% turn. The rotating handle component 514a can include holders in various rotational positions to allow controlled strokes of the working end on the bone. For example, holders can be located at every 45 ° of rotation or they can be located at any other rotational increment.
    [082] FIG. 17 represents an RF generator 530A and RF controller 530B connectable to an electrical connector 532 on cable component 514a with a plug connector indicated at 536. The RF generator is of the type known in the art for electrosurgical ablation. The outer sleeve 520 comprises a first polarity electrode indicated at 540A (+). However, any type of energy can be used with the device.
    [083] FIGS. 18A and 18B illustrate yet another variation of a working end of a device for creating cavities in the rigid tissue. As shown, the device 500 can include an extensible central sleeve 550 with a sharp tip 552 that is axially extendable from the passageway 554 of the assembly of the first and second sleeves 520 and 522 (FIG. 19). Sleeve 550 may also include a second polarity electrode indicated at 540B (-). Clearly, the first and second electrodes will be electrically isolated from each other. In a variation, and as shown in FIG. 19, the sleeve assembly can carry a thin sleeve 555 or an insulating polymer coating such as PEEK to electrically isolate the first 540A (+) polarity electrode from the second 540B (-) electrode. The electrode can be implanted by rotating the handle 558 on the impact surface of the cable component 514a (FIG. 17). The degree of extension of the central sleeve 550 can be optionally indicated by means of a sliding tab 557 on the cable. In the illustrated variation, the sliding tab is located on both sides of the cable component 514a (FIG. 17). Sleeve 550 can be configured to extend distally beyond the assembly of sleeves 520 and 522 at a distance of about 5 to 15 mm.
    [084] With reference to FIG. 19, the extensible central sleeve 550 may have a series of grooves in at least a distal part thereof to allow it to fold in cooperation with the assembly of the first and second sleeves 520 and 522. In the embodiment shown in FIG. 18B, the central sleeve 550 can optionally include a distal part that does not contain any grooves. However, additional variations include grooves on the distal part of the sleeve.
    [085] FIG. 19 also represents an electrically insulating collar 560 that extends length A to axially separate the first electrode of polarity 540A (+) from the second electrode of polarity 540B (-). The axial length A can be from about 0.5 to 10 mm, and is usually from 1 to 5 mm. The collar can be a temperature-resistant ceramic or polymer.
    [086] FIG. 19 also depicts a polymer sleeve 565 extending from the lumen in the center of the electrode sleeve 550. The polymer sleeve 565 can provide saline infusion or other fluids to the working end and / or be used to aspirate from the working end when in use. The distal part of the sleeve 550 may include one or more ports 566 therein to carry the fluid or aspirate the site.
    [087] In all other respects, the osteotome 500 system can be conducted on bone and articulated as described above. Electrodes 540A and 540B are operationally coupled to a radiofrequency generator as is known in the art to apply coagulative or ablative electrosurgical energy to the tissue. In FIG. 20, it can be seen that RF current 575 is indicated in the pathways between electrodes 540A and 540B as shown by lines 575. The RF generator 530A and controller 530B for use with the devices described here can include any number of power settings to control the size of the targeted coagulation or ablation area. For example, the RF generator and controller can have low (5 watts), medium (15 watts) and high (25 watts) power settings. The 530B controller can have a control algorithm that monitors the temperature of the electrodes and changes the energy input in order to maintain a constant temperature. At least one temperature sensing element (for example, a thermocouple) can be provided in different parts of the device. For example, and as shown in FIG. 19, a temperature detector element 577 may be provided at the distal end of the sleeve of the tip 550 of the sleeve while a second temperature detector element 578 may be provided near the distal tip to provide temperature feedback to the operator to indicate the region of the tissue. ablated during the application of RF energy. In one example, the second temperature sensing element was located approximately 15 to 20 mm from the distal tip.
    [088] FIG. 21 illustrates another variation of the articulation osteotome 600 with the characteristics of RF ablation. The variations of the illustrated osteotome 600 may be similar to the osteotome of FIGS. 17-18B. In this variation, the osteotome 600 has a cable 602 coupled to the stem assembly 610 as described above. The working end 610 again has an extensible assembly indicated at 615 in FIG. 21 which can be extended by rotating the cable part 622 with respect to the cable 602. The osteotome can be pivoted as described previously by rotating the cable part 620 with respect to the cable 602.
    [089] FIGS. 22A-22B are views of the working end 610 of FIG. 21 in a first non-extended configuration (FIG. 22A) and a second extended configuration (FIG. 22B). As can be seen in FIGS. 22A-22B, the extension part 615 comprises an axial rod 624 with a helical spring element 625 which is axially foldable and extendable. In one embodiment, the rod may be a tube member with ports 626 fluidly coupled to a lumen 628 therein. In some variations, the doors can either carry a fluid to the working end or can suck the fluid from the working end.
    [090] In FIGS. 22A-22B, it can be seen that the axial rod 624, the helical spring element 625 with the sharp tip 630 comprises a first electrode of polarity (+) coupled to the electrical source 530A and controller 530B as described previously. An insulator 632 separates the helical spring electrode 625 from the proximal part of the sleeve comprising electrodes of opposite polarity 640 (-). The RF electrodes can function as described above (see FIG. 20) to ablate tissue or otherwise deliver energy to the tissue.
    [091] In a variation, the extension part 615 can extend from a bent spring length of 2 mm, 3 mm, 4 mm or 5 mm to an extended spring length of 6 mm, 7 mm, 8 mm , 9 mm, 10 mm or more. At the working end 615 of the embodiment in FIG. 22B, the spring may comprise a flat rectangular wire which assists in centering the spring 625 around the stem 624, but can still bend to the overall short length, with the flat surfaces of the rectangular wire oriented towards the stack. However, other variations are within the scope of the variations described here.
    [092] The use of the 625 spring as an electrode provides significant improvements in energy management. This spring provides (i) a much larger electrode surface area and (ii) a much longer length of the relatively sharp edges provided through the rectangular wire - which provides the edges. Because the edges provide a low surface area, the concentration or density of the RF current is greater at the edges and allows the RF current to skip or arch. Both of these aspects of the invention - greater electrode surface area and longer electrode edge length - allow for much faster tissue ablation.
    [093] In one aspect of the invention, the surface area of the spring electrode 625 can be at least 40 mm2, at least 50 mm2, or at least 60 mm2 over the lengths of the spring electrode described above.
    [094] In another aspect of the invention, the total length of the 4 edges of the rectangular wire spring can be greater than 50 mm, greater than 100 mm or greater than 150 mm over the lengths of the spring electrode described above.
    [095] In an example used in the test, an osteotome 600 (as in FIG. 21-22B) was configured with a helical spring that has a folded length of 1.8 mm and an extended length of 7.5 mm. In this embodiment, the surface area of the 625 spring electrode when extended was 64.24 mm2 and the total length of the electrode edges was 171.52 mm (four edges at 42.88 mm per edge).
    [096] In a comparison test, a first osteotome without a helical electrode was compared against a second osteotome 600 with a helical electrode as in FIG. 22B. These devices were evaluated at different energy levels and different energy delivery intervals to determine the volume of ablation. The working ends of the devices have similar dimensions except for the coil spring electrode. In FIG. 23A, RF energy was delivered at a low-energy setting of 5 Watts. It can be seen in FIG. 23A that in a treatment interval of 120 seconds and 5W, the ablation volume was about 3 times faster with the helical electrode compared to the working end without the helical electrode (1.29 cc vs. 0.44 cc) .
    [097] Another comparison test of the same first osteotome 500 (FIG. 18B) and second osteotome 600 with a helical electrode (FIG. 22B) was evaluated at the highest energy level of 15 Watts. As can be seen in FIG. 23B, the RF energy in a treatment interval of 25 seconds and 15W, the ablation volume was again about 3 times faster with the helical electrode compared to the working end without the helical electrode (1.00 cc vs. 0, 37 cc). In FIG. 23B, the device without the helical electrode hindered off before 60 seconds passed, so that the data was not provided. The test shows that the helical electrode is well suited for any type of tissue or tumor ablation, with a 60-second ablation resulting in 1.63 cc of ablated tissue.
    [098] FIG. 24 schematically illustrates the osteotome 600 in use in a vertebral body, in which the RF current between electrodes 625 and 640 ablates a volume of tissue indicated at 640.
    [099] FIG. 25 illustrates another variation of an articulated osteotome 700 capable of delivering RF energy. Some variations of the device can be manufactured to be similar to the osteotome of FIGS. 17-18B. In a variation, the stem assembly 705 is similar to the previous examples in which the working end 710 carries an extensible element 725 which carries an electrode surface indicated at 727 in FIG. 25. Extendable element 725 can be driven by extending flexible sleeve 722 arranged in a lumen on a stem assembly 705. For example, flexible sleeve 722 and extensible element 725 can be extended by rotating a cable mechanism as described above. The osteotome is articulated as previously described by rotating a first part of the cable in relation to a second part of the cable.
    [100] Still with reference to FIG. 25, the extendable electrode 727 can be coupled to a first pole of an electrical source 530A, and the stem 705 can comprise the surface of the electrode of opposite polarity 740 coupled to a second pole of electrical source 530A. An insulating collar separates the first and second surfaces of the polarity electrode 727 and 740. In some variations, the collar carries an insulating coating or is made from an insulating material. As can be seen in FIG. 25, the rear-facing surface of the extensible element 725 carries an electrical insulator 744 including, but not limited to, a paint, coating, tape, polymer, ceramic or similar. In addition, the internal radius of the articulated rod 705 carries an electrical insulator 745 which again can be a paint, coating, tape, polymer body part, ceramic or similar.
    [101] FIG. 26 represents the hinged working end of FIG. 25 in a vertebral body delivering RF energy to the tissue in which the insulated surfaces 744 and 745 direct heating of the tissue on the opposite side of the device so that energy delivery occurs far from the vertebral channel 748. In some variations, the energy produces a region ablated indicated at 750. However, the devices described here can include any variety of energy management, whether ablative or non-ablative.
    [102] FIG. 27 represents another realization of the articulation osteotome 800 with RF ablation functionality. In one embodiment, the rod assembly 805 is similar to the previous embodiments with the working end 810 carrying a plurality of extensible electrodes 825 that can be extended via a drive mechanism on the cable. The osteotome can articulate as previously described by rotating a first part of the cable in relation to a second part of the cable. Extendable electrodes 825 cooperate with the rod electrode 840 as described above, and are separated from the rod electrode 840 by insulating sleeves 832. The embodiment of FIG. 27 also carries an insulator extending axially 845 in the inner radius of the stem.
    [103] In general, osteotome 800 of FIG. 27 comprises a cable having a connector for electrically coupling the device to a power supply, a rod 805 having a shaft extending from the cable to a working end 810, wherein a first conductive part of the rod is electrically coupled to a first pole of an RF power supply, a plurality of electrode elements extendable 825 from the rod, where the extendable elements 825 are attachable to a second pole of the power supply, so that when triggered, current flows between the extensible elements and the stem, and in which the extensible elements are radially asymmetric with respect to the axis of the stem 805.
    [104] FIG. 28 represents the hinged working end of FIG. 27 in a vertebral body applying energy to the tissue in which the plurality of the extended electrodes 825 administers energy in a region 850 that is spaced away from the vertebral channel 748.
    [105] FIG. 29 illustrates an alternative hinge ablation device 900 with RF ablation functionality. In one embodiment, the rod or extension part 905 comprises two components. A component 910 can be a hinge assembly as in the previous embodiments or it can be a NiTi sleeve that extends to the working end 910 and carries an extendable electrode 925 that can be extended via a trigger mechanism on the cable. The second component 930 of the extension part comprises a flexible polymer sleeve or a NiTi sleeve that has a lumen in it to charge a flow medium for outlet 932 at the working end 910. Electrodes 925 and 940 work as described above.
    [106] The embodiment of FIG. 29 includes a source 960 of an electrically and / or thermally insulating fluid 965 gel that can be injected into the tissue site to protect the selected tissue from ablation. In general, an osteotome of the invention comprises a cable having a connector for electrically coupling the osteotome device to a power supply, a rod extending from the cable to a working end, where a first and second conductive parts of the rod are attachable to a first and second pole of a power supply, and a lumen on the stem attachable to a source of the fluid insulating medium.
    [107] FIG. 30 represents the hinged working end of FIG. 29 in a vertebral body by applying RF energy to ablate the tissue in which an insulating gel 965 is injected to protect the vertebral canal 748 to thereby create an ablation region 950 away from the vertebral canal.
    [108] Although the particular embodiments of the present invention have been described in detail above, it will be understood that this description is for illustrative purposes only and the above description of the invention is not exhaustive. The specific features of the invention are shown in some drawings and not in others, and this is for convenience only and any feature can be combined with another according to the invention. A number of variations and alternatives will be apparent to a person skilled in the art. Such alternatives and variations are intended to be included within the scope of the claims. Particular features that are presented in the dependent claims can be combined and fall within the scope of the invention. The invention also encompasses realizations even if the dependent claims were written alternatively in a multiple dependent claim format with reference to other independent claims.
    权利要求:
    Claims (11)
    [0001]
    1. MEDICAL DEVICE (700) FOR ABLATION OF TISSUE INSIDE A BONE OF A PATIENT, characterized by the medical device (700) comprising: a proximal cable (115) that is configured to electrically couple the medical device (700) to a generator radio frequency (530A); a sleeve (705) extending distally from the proximal cable, where the sleeve (105) comprises a first electrode (740) which is electrically coupled to a first pole of the radio frequency generator (530A) when the radio frequency generator (530A) it is electrically coupled to the medical device (700); a driver (142) which, after being actuated, is configured to cause the sleeve (705) to articulate so that the sleeve (705) forms a curved configuration, where the sleeve (705) is configured to remain in the curved configuration by means of applying a driving force or a rotational force to the proximal cable (115), such that the curved configuration creates or expands a cavity in the patient's bone; and an elongated axis (725) which is at least partially disposed within a lumen (112) of the sleeve (705), wherein the elongated axis (725) is configured to transition from a retracted configuration to an extended configuration; wherein a distal portion of the elongated shaft (725) comprises: a second electrode (727) which is electrically coupled to a second pole of the radio frequency generator (530A) when the radio frequency generator (530A) is electrically connected to the medical device (100 ); and an axially extending insulator (744) which is disposed next to the second electrode (727).
    [0002]
    2. MEDICAL DEVICE (700), according to claim 1, characterized in that it also comprises a second driver, in which the activation of the second driver when a distal part of the medical device (100) is positioned inside the patient's bone causes current flows between the second electrode (727) and the first electrode (740) through the tissue in the patient's bone.
    [0003]
    3. MEDICAL DEVICE (700), according to claim 1, characterized in that, when the elongated axis (725) is in the retracted configuration and the sleeve (705) is in the curved configuration, the axially extending insulator (744) is adjacent to a concave side of the curved configuration.
    [0004]
    4. MEDICAL DEVICE (700), according to claim 1, characterized in that the insulator (744) is positioned so that, when the medical device (100) is activated for ablation, the current is preferably directed to one side of the device ( 100) that is in front of the insulator (744).
    [0005]
    MEDICAL DEVICE (700) according to claim 1, characterized in that the sleeve (705) comprises a plurality of notches (146), wherein the plurality of notches (146) is arranged on a concave side of the sleeve (705) when the sleeve (705) is in the curved configuration.
    [0006]
    6. MEDICAL DEVICE (700), according to claim 1, characterized in that the sleeve (705) comprises an axially extending insulator (745) disposed adjacent to a distal end of the sleeve (705), wherein the insulator (744) it does not extend around a circumference of the sleeve (705).
    [0007]
    MEDICAL DEVICE (700) according to claim 1, characterized in that the lumen (112) of the sleeve (705) extends through a door at a distal end of the sleeve (705).
    [0008]
    8. MEDICAL DEVICE (700), according to claim 1, characterized in that the first electrode (745) is separated from the second electrode by an insulating collar (732).
    [0009]
    9. MEDICAL DEVICE (700), according to claim 1, characterized in that it further comprises a sharp point at a distal end of the sleeve (705), in which the sharp point is configured for bone penetration.
    [0010]
    10. MEDICAL DEVICE (900) FOR ABLATION OF TISSUE INSIDE A PATIENT BONE (900), the medical device comprising: a cable (115) that is configured to electrically couple the medical device (100) to a radio frequency generator (530A); an elongated axis (905) comprising a first electrode (940) and a second electrode (925) which is spatially separated from the first electrode (940), where, when the medical device (900) is coupled to the radio frequency generator (530A) , the first electrode (940) is electrically coupled to a first pole of the radio frequency generator (530A) and the second (925) the electrode is electrically coupled to a second pole of the radio frequency generator (530A); a driver (142) which, after actuation, is configured to cause the elongated axis (905) to articulate, so that the elongated axis (905) forms a curved configuration, in which the elongated axis (905) is configured to remain in the curved configuration by applying a driving force or rotational force to the cable (115) so that the curved configuration creates or expands a cavity in the patient's bone; and an elongated lumen (112) that extends longitudinally through the elongated axis (905), where the lumen (112) is in fluid communication with one or more distal lateral openings (932) that facilitate the preferential delivery of fluid media to a elongated shaft side (905).
    [0011]
    11. MEDICAL DEVICE (900), according to claim 10, characterized in that the first electrode (940) is axially displaceable in relation to the second electrode (925).
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012027708B1|2021-03-09|medical device for ablation of tissue within a patient's bone
    US10327841B2|2019-06-25|System for use in treatment of vertebral fractures
    US10123809B2|2018-11-13|System for use in treatment of vertebral fractures
    US10299805B2|2019-05-28|Systems for treating a vertebral body
    US10028784B2|2018-07-24|Methods and systems for use in controlling tissue ablation volume by temperature monitoring
    EP2521501A2|2012-11-14|Systems and methods for navigating an instrument through bone
    同族专利:
    公开号 | 公开日
    US9125671B2|2015-09-08|
    EP2563233B1|2020-04-01|
    WO2011137377A1|2011-11-03|
    US9743938B2|2017-08-29|
    BR112012027708A2|2019-09-10|
    BR112012027708A8|2019-12-10|
    US20180028199A1|2018-02-01|
    EP2563233A1|2013-03-06|
    US20150335336A1|2015-11-26|
    EP2563233A4|2014-11-19|
    CN102958456B|2015-12-16|
    CN106618669A|2017-05-10|
    US20110295262A1|2011-12-01|
    CN102958456A|2013-03-06|
    US10624652B2|2020-04-21|
    CN106618669B|2019-11-12|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US2688329A|1953-03-19|1954-09-07|American Cystoscope Makers Inc|Catheter|
    US3140623A|1961-08-29|1964-07-14|Pendleton Tool Ind Inc|Predetermined torque release wrench|
    US3228400A|1962-12-03|1966-01-11|Thomas A Armao|Cryogenic capsule probes|
    US3503385A|1965-09-27|1970-03-31|Cordis Corp|Guidable catheter assembly and manipulator therefor|
    US3625200A|1969-08-26|1971-12-07|Us Catheter & Instr Corp|Controlled curvable tip member|
    DE1953835B2|1969-10-25|1972-02-24|Linde Ag, 6200 Wiesbaden|CRYOSURGICAL DEVICE|
    US3664344A|1970-09-15|1972-05-23|Brymill Corp|Tyned cryosurgical probe|
    US3908637A|1974-04-22|1975-09-30|Louis W Doroshow|Rigid urethral instrument|
    DE2501683C3|1975-01-17|1979-11-29|Ernst Leitz Wetzlar Gmbh, 6300 Wetzlar|Polymer composite material for prosthetic use and process for its manufacture|
    US4033331A|1975-07-17|1977-07-05|Guss Stephen B|Cardiac catheter and method of using same|
    US4900303A|1978-03-10|1990-02-13|Lemelson Jerome H|Dispensing catheter and method|
    US4578061A|1980-10-28|1986-03-25|Lemelson Jerome H|Injection catheter and method|
    EP0006414B1|1978-06-29|1984-10-10|Osteo Ag|Carbon fiber reinforced bone cement|
    US4276880A|1978-09-14|1981-07-07|Oscar Malmin|Cannula and process|
    US4294251A|1978-10-17|1981-10-13|Greenwald A Seth|Method of suction lavage|
    US4236520A|1978-12-04|1980-12-02|Anderson Mark L|Fluid drain or injection tube for an animal's udder|
    DE2944710A1|1979-11-06|1981-05-07|Christos Dr. Dimakos|DEVICE FOR REMOVING A BONE CEMENT TUBE IN A REIMPLANTATION OF AN ARTIFICIAL THIGH NECK|
    DE2949368A1|1979-12-07|1981-06-11|Hilti AG, 9494 Schaan|DEVICE FOR DELIVERING ONE OR MULTI-COMPONENT DIMENSIONS|
    US4411266A|1980-09-24|1983-10-25|Cosman Eric R|Thermocouple radio frequency lesion electrode|
    US5017627A|1980-10-09|1991-05-21|National Research Development Corporation|Composite material for use in orthopaedics|
    US4337773A|1980-10-20|1982-07-06|Raftopoulos Demetrios D|Method of and device for placing a barrier in a cavity provided in a bone shaft|
    US4719968A|1981-01-15|1988-01-19|Speros Phillip C|Heat exchanger|
    US4399814A|1981-04-27|1983-08-23|Massachusetts Institute Of Technology|Method and apparatus for pressure-coated bones|
    US4473077A|1982-05-28|1984-09-25|United States Surgical Corporation|Surgical stapler apparatus with flexible shaft|
    US4595006A|1982-08-16|1986-06-17|Burke Dennis W|Apparatus for cemented implantation of prostheses|
    US4456017A|1982-11-22|1984-06-26|Cordis Corporation|Coil spring guide with deflectable tip|
    DE3325111A1|1983-07-12|1985-01-24|Merck Patent Gmbh, 6100 Darmstadt|IMPLANTATION MATERIALS|
    US4722948A|1984-03-16|1988-02-02|Dynatech Corporation|Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone|
    CA1227902A|1984-04-02|1987-10-13|Raymond G. Tronzo|Fenestrated hip screw and method of augmentedinternal fixation|
    US4619263A|1984-05-30|1986-10-28|Advanced Cardiovascular Systems, Inc.|Adjustable rotation limiter device for steerable dilatation catheters|
    US4586923A|1984-06-25|1986-05-06|Cordis Corporation|Curving tip catheter|
    US5114414A|1984-09-18|1992-05-19|Medtronic, Inc.|Low profile steerable catheter|
    US4888366A|1984-10-24|1989-12-19|Collagen Corporation|Inductive collagen-based bone repair preparations|
    US5246457A|1985-03-28|1993-09-21|Collagen Corporation|Xenogeneic collagen/mineral preparations in bone repair|
    US4668295A|1985-04-25|1987-05-26|University Of Dayton|Surgical cements|
    US4627434A|1985-05-03|1986-12-09|Murray William M|Bone cement system and method|
    US4742817A|1985-05-15|1988-05-10|Olympus Optical Co., Ltd.|Endoscopic apparatus having a bendable insertion section|
    CH667209A5|1985-07-02|1988-09-30|Sulzer Ag|MEDICAL DEPOT PROBE.|
    US4641654A|1985-07-30|1987-02-10|Advanced Cardiovascular Systems, Inc.|Steerable balloon dilatation catheter assembly having dye injection and pressure measurement capabilities|
    US4998923A|1988-08-11|1991-03-12|Advanced Cardiovascular Systems, Inc.|Steerable dilatation catheter|
    US4846814A|1986-01-16|1989-07-11|Sherwood Medical Company|Non-whip catheter|
    US4795602A|1986-03-19|1989-01-03|Pretchel David A|Two pin shunt and molding method|
    DE3613213A1|1986-04-18|1987-10-22|Merck Patent Gmbh|TRICALCIUMPHOSPHATE FOR IMPLANTATION MATERIALS|
    US4747840A|1986-09-17|1988-05-31|Ladika Joseph E|Selective pulmonary arteriograph catheter|
    US5085861A|1987-03-12|1992-02-04|The Beth Israel Hospital Association|Bioerodable implant composition comprising crosslinked biodegradable polyesters|
    US4843112A|1987-03-12|1989-06-27|The Beth Israel Hospital Association|Bioerodable implant composition|
    US4748969A|1987-05-07|1988-06-07|Circon Corporation|Multi-lumen core deflecting endoscope|
    US4898156A|1987-05-18|1990-02-06|Mitek Surgical Products, Inc.|Suture anchor|
    US4784638A|1987-09-17|1988-11-15|Neurodynamics, Inc.|Angled hole ventricular catheter and method of making same|
    US4865586A|1987-09-21|1989-09-12|Martha Hedberg|Suction stylet for endotracheal intubation|
    CN88203061U|1988-02-05|1988-11-23|黄传诗|Puncture needle for viscera|
    IT1234978B|1988-06-01|1992-06-09|Tecres Spa|TWO-STAGE CEMENTITIOUS MIXTURE, PARTICULARLY SUITABLE FOR ORTHOPEDIC USES.|
    US4961731A|1988-06-09|1990-10-09|Sherwood Medical Company|Angiographic catheter with balanced dye injection openings|
    US7431722B1|1995-02-27|2008-10-07|Warsaw Orthopedic, Inc.|Apparatus including a guard member having a passage with a non-circular cross section for providing protected access to the spine|
    US5088991A|1988-07-14|1992-02-18|Novoste Corporation|Fuseless soft tip angiographic catheter|
    US5156606A|1988-10-11|1992-10-20|Zimmer, Inc.|Method and apparatus for removing pre-placed prosthetic joints and preparing for their replacement|
    US5264214A|1988-11-21|1993-11-23|Collagen Corporation|Composition for bone repair|
    US5296026A|1988-12-02|1994-03-22|Monroe Eugene A|Phosphate glass cement|
    US4982730A|1988-12-21|1991-01-08|Lewis Jr Royce C|Ultrasonic wound cleaning method and apparatus|
    US4963151A|1988-12-28|1990-10-16|Trustees Of The University Of Pennsylvania|Reinforced bone cement, method of production thereof and reinforcing fiber bundles therefor|
    US5372587A|1989-01-09|1994-12-13|Pilot Cariovascular Systems, Inc.|Steerable medical device|
    US5378234A|1993-03-15|1995-01-03|Pilot Cardiovascular Systems, Inc.|Coil polymer composite|
    US5480382A|1989-01-09|1996-01-02|Pilot Cardiovascular Systems, Inc.|Steerable medical device|
    US4969888A|1989-02-09|1990-11-13|Arie Scholten|Surgical protocol for fixation of osteoporotic bone using inflatable device|
    US4969870A|1989-06-07|1990-11-13|The Regents Of The University Of California|Method and apparatus for intraosseous infusions|
    US5049137A|1989-09-08|1991-09-17|Thompson Jeffrey E|Prepackaged syringe and catheter apparatus for deep administration of a fluid, and method of making same|
    US4961730A|1989-09-29|1990-10-09|Poncy George W|Hypodermic syringe with sliding cap|
    US5196201A|1989-10-20|1993-03-23|Bioapatite Ab|Implant material composition, preparation thereof as well as uses thereof and implant product obtainable therefrom|
    US5295980A|1989-10-30|1994-03-22|Ersek Robert A|Multi-use cannula system|
    US5059193A|1989-11-20|1991-10-22|Spine-Tech, Inc.|Expandable spinal implant and surgical method|
    US5116305A|1990-02-01|1992-05-26|Abiomed, Inc.|Curved intra aortic balloon with non-folding inflated balloon membrane|
    US5152744A|1990-02-07|1992-10-06|Smith & Nephew Dyonics|Surgical instrument|
    US5197971A|1990-03-02|1993-03-30|Bonutti Peter M|Arthroscopic retractor and method of using the same|
    US5092891A|1990-03-08|1992-03-03|Kummer Frederick J|Cement plug for the medullary canal of a bone and coacting tool for installing same|
    NL9000833A|1990-04-09|1991-11-01|Cordis Europ|ANGIOGRAPHY CATHETER.|
    US5266248A|1990-05-10|1993-11-30|Torao Ohtsuka|Method of producing hydroxylapatite base porous beads filler for an organism|
    US5103804A|1990-07-03|1992-04-14|Boston Scientific Corporation|Expandable tip hemostatic probes and the like|
    US6080801A|1990-09-13|2000-06-27|Klaus Draenert|Multi-component material and process for its preparation|
    ZA917281B|1990-09-26|1992-08-26|Cryomedical Sciences Inc|Cryosurgical instrument and system and method of cryosurgery|
    DE4033343A1|1990-10-19|1992-04-23|Draenert Klaus|MATERIAL AS THE STARTING MATERIAL FOR THE PRODUCTION OF BONE CEMENT AND METHOD FOR THE PRODUCTION THEREOF|
    US5454365A|1990-11-05|1995-10-03|Bonutti; Peter M.|Mechanically expandable arthroscopic retractors|
    US5147334A|1991-01-02|1992-09-15|Moss James P|Catheter for cholangiography|
    US5231989A|1991-02-15|1993-08-03|Raychem Corporation|Steerable cannula|
    AU660444B2|1991-02-15|1995-06-29|Ingemar H. Lundquist|Torquable catheter and method|
    US5161715A|1991-03-25|1992-11-10|Giannuzzi Anthony C|Double-barreled epoxy injection gun|
    US5368598A|1991-04-19|1994-11-29|Hasson; Harrith M.|Method of manipulating an uterus using a bendable manipulator|
    US5188619A|1991-04-24|1993-02-23|Gene E. Myers Enterprises, Inc.|Internal thoractic artery catheter|
    US5112303A|1991-05-02|1992-05-12|Pudenz-Schulte Medical Research Corporation|Tumor access device and method for delivering medication into a body cavity|
    US5356629A|1991-07-12|1994-10-18|United States Surgical Corporation|Composition for effecting bone repair|
    US5211631A|1991-07-24|1993-05-18|Sheaff Charles M|Patient warming apparatus|
    US5308342A|1991-08-07|1994-05-03|Target Therapeutics, Inc.|Variable stiffness catheter|
    US5285795A|1991-09-12|1994-02-15|Surgical Dynamics, Inc.|Percutaneous discectomy system having a bendable discectomy probe and a steerable cannula|
    US5697281A|1991-10-09|1997-12-16|Arthrocare Corporation|System and method for electrosurgical cutting and ablation|
    US7179255B2|1995-06-07|2007-02-20|Arthrocare Corporation|Methods for targeted electrosurgery on contained herniated discs|
    US6602248B1|1995-06-07|2003-08-05|Arthro Care Corp.|Methods for repairing damaged intervertebral discs|
    US5662680A|1991-10-18|1997-09-02|Desai; Ashvin H.|Endoscopic surgical instrument|
    US5697909A|1992-01-07|1997-12-16|Arthrocare Corporation|Methods and apparatus for surgical cutting|
    US7270661B2|1995-11-22|2007-09-18|Arthocare Corporation|Electrosurgical apparatus and methods for treatment and removal of tissue|
    US5681282A|1992-01-07|1997-10-28|Arthrocare Corporation|Methods and apparatus for ablation of luminal tissues|
    US5766153A|1993-05-10|1998-06-16|Arthrocare Corporation|Methods and apparatus for surgical cutting|
    US6726684B1|1996-07-16|2004-04-27|Arthrocare Corporation|Methods for electrosurgical spine surgery|
    US7104986B2|1996-07-16|2006-09-12|Arthrocare Corporation|Intervertebral disc replacement method|
    US5284128A|1992-01-24|1994-02-08|Applied Medical Resources Corporation|Surgical manipulator|
    US5336699A|1992-02-20|1994-08-09|Orthopaedic Research Institute|Bone cement having chemically joined reinforcing fillers|
    AT208217T|1992-02-28|2001-11-15|Cohesion Tech Inc|INJECTABLE, CERAMIC COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF|
    US5269750A|1992-06-22|1993-12-14|Stryker Corporation|Tip unit for fluid transfer surgical handpiece|
    US5342299A|1992-07-06|1994-08-30|Catheter Imaging Systems|Steerable catheter|
    US5334626A|1992-07-28|1994-08-02|Zimmer, Inc.|Bone cement composition and method of manufacture|
    US5343877A|1992-09-09|1994-09-06|University Of Iowa Research Foundation|Orthopedic implant and method|
    US5380307A|1992-09-30|1995-01-10|Target Therapeutics, Inc.|Catheter with atraumatic drug delivery tip|
    US5549542A|1992-11-17|1996-08-27|Life Medical Technologies, Inc.|Deflectable endoscope|
    FR2697995B1|1992-11-19|1994-12-30|Celsa Lg|Removable blood filtration device, with variable rigidity, implantable in the body of a patient and allowing the injection of a treating product.|
    US5389073A|1992-12-01|1995-02-14|Cardiac Pathways Corporation|Steerable catheter with adjustable bend location|
    US5282821A|1993-01-26|1994-02-01|Donahue John R|Adjustable surgical instrument|
    US5620447A|1993-01-29|1997-04-15|Smith & Nephew Dyonics Inc.|Surgical instrument|
    US5833692A|1993-01-29|1998-11-10|Smith & Nephew, Inc.|Surgical instrument|
    EP0684787B1|1993-02-19|2004-05-12|Boston Scientific Corporation|Surgical extractor|
    US7052493B2|1996-10-22|2006-05-30|Epicor Medical, Inc.|Methods and devices for ablation|
    US5628771A|1993-05-12|1997-05-13|Olympus Optical Co., Ltd.|Electromagnetic-wave thermatological device|
    US5531715A|1993-05-12|1996-07-02|Target Therapeutics, Inc.|Lubricious catheters|
    JPH0751379A|1993-06-24|1995-02-28|Cardiovascular Dynamics Inc|Injection catheter, intravascular site treating method, and production of catheter|
    US5860974A|1993-07-01|1999-01-19|Boston Scientific Corporation|Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft|
    US5571088A|1993-07-01|1996-11-05|Boston Scientific Corporation|Ablation catheters|
    US5431639A|1993-08-12|1995-07-11|Boston Scientific Corporation|Treating wounds caused by medical procedures|
    US5616121A|1993-08-17|1997-04-01|Mckay; Douglas W.|Method for alleviating pain in a wound|
    US5431168A|1993-08-23|1995-07-11|Cordis-Webster, Inc.|Steerable open-lumen catheter|
    US5449351A|1993-09-09|1995-09-12|Zohmann; Walter A.|Atraumatic needle for lumbar puncture|
    US5385563A|1993-09-14|1995-01-31|The Kendall Company|Urodynamic catheter|
    US5360416A|1993-09-30|1994-11-01|Sherwood Medical Company|Thin-walled anesthesia needles|
    US6001093A|1993-10-15|1999-12-14|Ep Technologies, Inc.|Systems and methods for creating long, thin lesions in body tissue|
    WO1995010225A1|1993-10-15|1995-04-20|Ep Technologies, Inc.|Multiple electrode element for mapping and ablating|
    US5599346A|1993-11-08|1997-02-04|Zomed International, Inc.|RF treatment system|
    US5458597A|1993-11-08|1995-10-17|Zomed International|Device for treating cancer and non-malignant tumors and methods|
    US5810804A|1995-08-15|1998-09-22|Rita Medical Systems|Multiple antenna ablation apparatus and method with cooling element|
    US5449301A|1993-11-17|1995-09-12|Berg Technology, Inc.|Shunt connector|
    US5514137A|1993-12-06|1996-05-07|Coutts; Richard D.|Fixation of orthopedic devices|
    US6719773B1|1998-06-01|2004-04-13|Kyphon Inc.|Expandable structures for deployment in interior body regions|
    US6248110B1|1994-01-26|2001-06-19|Kyphon, Inc.|Systems and methods for treating fractured or diseased bone using expandable bodies|
    US7044954B2|1994-01-26|2006-05-16|Kyphon Inc.|Method for treating a vertebral body|
    US7166121B2|1994-01-26|2007-01-23|Kyphon Inc.|Systems and methods using expandable bodies to push apart cortical bone surfaces|
    US20060100635A1|1994-01-26|2006-05-11|Kyphon, Inc.|Inflatable device for use in surgical protocol relating to fixation of bone|
    KR100355207B1|1994-01-26|2003-01-24|마크 에이 레일리|Improved inflatable device for use in surgical protocol relating to fixation of bone|
    US6283960B1|1995-10-24|2001-09-04|Oratec Interventions, Inc.|Apparatus for delivery of energy to a surgical site|
    US5571189A|1994-05-20|1996-11-05|Kuslich; Stephen D.|Expandable fabric implant for stabilizing the spinal motion segment|
    US5514130A|1994-10-11|1996-05-07|Dorsal Med International|RF apparatus for controlled depth ablation of soft tissue|
    US5554114A|1994-10-20|1996-09-10|Micro Therapeutics, Inc.|Infusion device with preformed shape|
    US5858003A|1994-10-20|1999-01-12|Children's Medical Center Corporation|Systems and methods for promoting tissue growth|
    US5779688A|1994-10-28|1998-07-14|Intella Interventional Systems, Inc.|Low profile balloon-on-a-wire catheter with shapeable and/or deflectable tip and method|
    US5489275A|1994-11-14|1996-02-06|Ep Technologies, Inc.|Identification ring for catheter|
    AU4242996A|1994-11-23|1996-06-17|Navarre Biomedical, Ltd.|Flexible catheter|
    US5535922A|1994-11-29|1996-07-16|Tah Industries, Inc.|Caulking gun dispensing module for multi-component cartridge|
    EP0801582A1|1995-01-04|1997-10-22|Advanced Cardiovascular Systems, Inc.|Catheter shaft with an oblong transverse cross section|
    US6291547B1|1995-02-08|2001-09-18|Materials Evolution And Development Usa Inc.|Bone cement compositions comprising fused fibrous compounds|
    US5947964A|1995-03-03|1999-09-07|Neothermia Corporation|Methods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue|
    US6106524A|1995-03-03|2000-08-22|Neothermia Corporation|Methods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue|
    US6312428B1|1995-03-03|2001-11-06|Neothermia Corporation|Methods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue|
    US5571085A|1995-03-24|1996-11-05|Electro-Catheter Corporation|Steerable open lumen catheter|
    US5741320A|1995-05-02|1998-04-21|Heart Rhythm Technologies, Inc.|Catheter control system having a pulley|
    US6575969B1|1995-05-04|2003-06-10|Sherwood Services Ag|Cool-tip radiofrequency thermosurgery electrode system for tumor ablation|
    US6953594B2|1996-10-10|2005-10-11|Etex Corporation|Method of preparing a poorly crystalline calcium phosphate and methods of its use|
    US6280413B1|1995-06-07|2001-08-28|Medtronic Ave, Inc.|Thrombolytic filtration and drug delivery catheter with a self-expanding portion|
    US5725568A|1995-06-27|1998-03-10|Scimed Life Systems, Inc.|Method and device for recanalizing and grafting arteries|
    AU6499596A|1995-07-18|1997-02-18|Edwards, Garland U.|Flexible shaft|
    US5681289A|1995-08-14|1997-10-28|Medicinelodge Inc.|Chemical dispensing system|
    US5637091A|1995-08-31|1997-06-10|Hakky; Said I.|Collapsible catheter|
    US5620467A|1995-10-10|1997-04-15|Incontrol, Inc.|Implantable atrial defibrillator having cardioverting output voltage limiting for simulating larger storage capacitors|
    AT275880T|1995-10-13|2004-10-15|Transvascular Inc|DEVICE FOR AVOIDING ARTERIAL NARROWS AND / OR FOR CARRYING OUT OTHER TRANSVASCULAR INTERVENTIONS|
    US5776193A|1995-10-16|1998-07-07|Orquest, Inc.|Bone grafting matrix|
    US5624396A|1995-10-30|1997-04-29|Micro Therapeutics, Inc.|Longitudinally extendable infusion device|
    US5709697A|1995-11-22|1998-01-20|United States Surgical Corporation|Apparatus and method for removing tissue|
    US20030069522A1|1995-12-07|2003-04-10|Jacobsen Stephen J.|Slotted medical device|
    US5833632A|1995-12-07|1998-11-10|Sarcos, Inc.|Hollow guide wire apparatus catheters|
    US5914356A|1996-12-06|1999-06-22|Orthovita, Inc.|Bioactive load bearing bone bonding compositions|
    GB9600377D0|1996-01-09|1996-03-13|Gyrus Medical Ltd|Electrosurgical instrument|
    US5860952A|1996-01-11|1999-01-19|C. R. Bard, Inc.|Corporeal access tube assembly and method|
    US5885258A|1996-02-23|1999-03-23|Memory Medical Systems, Inc.|Medical instrument with slotted memory metal tube|
    US6228052B1|1996-02-29|2001-05-08|Medtronic Inc.|Dilator for introducer system having injection port|
    US5695513A|1996-03-01|1997-12-09|Metagen, Llc|Flexible cutting tool and methods for its use|
    US5735829A|1996-03-22|1998-04-07|Cherian; George|Intercostal anesthetic infusion catheter|
    US6110155A|1996-04-30|2000-08-29|Medtronic, Inc.|Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis|
    WO1997041924A1|1996-05-06|1997-11-13|Thermal Therapeutics, Inc.|Transcervical intrauterine applicator for intrauterine hyperthermia|
    US5700157A|1996-06-05|1997-12-23|D-Link Corporation|Electric jack with display means|
    US5681317A|1996-06-12|1997-10-28|Johnson & Johnson Professional, Inc.|Cement delivery system and method|
    US6312454B1|1996-06-13|2001-11-06|Nitinol Devices & Components|Stent assembly|
    US6136885A|1996-06-14|2000-10-24|3M Innovative Proprerties Company|Glass ionomer cement|
    GB2314274A|1996-06-20|1997-12-24|Gyrus Medical Ltd|Electrode construction for an electrosurgical instrument|
    US6066176A|1996-07-11|2000-05-23|Oshida; Yoshiki|Orthopedic implant system|
    US5820592A|1996-07-16|1998-10-13|Hammerslag; Gary R.|Angiographic and/or guide catheter|
    AT260072T|1996-07-18|2004-03-15|Implant Innovations Inc|MOTOR-DRIVEN OSTEOTOMY TOOLS FOR COMPRESSING BONE TISSUE|
    GB9616267D0|1996-08-02|1996-09-11|Ranier Ltd|Balloon catheter|
    CA2269282A1|1996-10-23|1998-04-30|Oratec Interventions, Inc.|Method and apparatus for treating intervertebral discs|
    US6126682A|1996-08-13|2000-10-03|Oratec Interventions, Inc.|Method for treating annular fissures in intervertebral discs|
    US5980504A|1996-08-13|1999-11-09|Oratec Interventions, Inc.|Method for manipulating tissue of an intervertebral disc|
    US6280473B1|1996-08-19|2001-08-28|Macropore, Inc.|Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration|
    US5905000A|1996-09-03|1999-05-18|Nanomaterials Research Corporation|Nanostructured ion conducting solid electrolytes|
    US5855577A|1996-09-17|1999-01-05|Eclipse Surgical Technologies, Inc.|Bow shaped catheter|
    US5891027A|1996-10-21|1999-04-06|Irvine Biomedical, Inc.|Cardiovascular catheter system with an inflatable soft tip|
    US5800408A|1996-11-08|1998-09-01|Micro Therapeutics, Inc.|Infusion device for distributing infusate along an elongated infusion segment|
    US5902839A|1996-12-02|1999-05-11|Northwestern University|Bone cement and method of preparation|
    US6332880B1|1996-12-19|2001-12-25|Ep Technologies, Inc.|Loop structures for supporting multiple electrode elements|
    US6030360A|1996-12-30|2000-02-29|Biggs; Robert C.|Steerable catheter|
    US6146355A|1996-12-30|2000-11-14|Myelotec, Inc.|Steerable catheter|
    US6013591A|1997-01-16|2000-01-11|Massachusetts Institute Of Technology|Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production|
    US5931829A|1997-01-21|1999-08-03|Vasca, Inc.|Methods and systems for establishing vascular access|
    JP3527378B2|1997-01-31|2004-05-17|テルモ株式会社|Contrast catheter|
    JP2002515801A|1997-02-12|2002-05-28|オーレイテックインターヴェンションズインコーポレイテッド|Concave tip for arthroscopic surgery|
    EP1011464B1|1997-03-07|2008-01-23|Disc-O-Tech Medical Technologies, Ltd.|Systems for percutaneous bone and spinal stabilization, fixation and repair|
    US5847046A|1997-03-12|1998-12-08|United States Surgical Corporation|Biodegradable bone cement|
    US6063078A|1997-03-12|2000-05-16|Medtronic, Inc.|Method and apparatus for tissue ablation|
    US5876373A|1997-04-04|1999-03-02|Eclipse Surgical Technologies, Inc.|Steerable catheter|
    US6524296B1|1997-04-17|2003-02-25|Medtronic, Inc.|Vessel cannula having properties varying along the axial length|
    US6165166A|1997-04-25|2000-12-26|Schneider Inc.|Trilayer, extruded medical tubing and medical devices incorporating such tubing|
    US5810867A|1997-04-28|1998-09-22|Medtronic, Inc.|Dilatation catheter with varied stiffness|
    US5849028A|1997-05-16|1998-12-15|Irvine Biomedical, Inc.|Catheter and method for radiofrequency ablation of cardiac tissue|
    US6428894B1|1997-06-04|2002-08-06|International Business Machines Corporation|Tunable and removable plasma deposited antireflective coatings|
    US5851212A|1997-06-11|1998-12-22|Endius Incorporated|Surgical instrument|
    US6048346A|1997-08-13|2000-04-11|Kyphon Inc.|Systems and methods for injecting flowable materials into bones|
    US5972015A|1997-08-15|1999-10-26|Kyphon Inc.|Expandable, asymetric structures for deployment in interior body regions|
    US5924976A|1997-08-21|1999-07-20|Stelzer; Paul|Minimally invasive surgery device|
    US5921956A|1997-09-24|1999-07-13|Smith & Nephew, Inc.|Surgical instrument|
    US6165173A|1997-10-06|2000-12-26|Somnus Medical Technologies, Inc.|Memory for regulating device utilization and behavior|
    US6309420B1|1997-10-14|2001-10-30|Parallax Medical, Inc.|Enhanced visibility materials for implantation in hard tissue|
    WO1999025280A1|1997-11-14|1999-05-27|Boston Scientific Limited|Multi-sheath delivery catheter|
    US6280441B1|1997-12-15|2001-08-28|Sherwood Services Ag|Apparatus and method for RF lesioning|
    US5997581A|1997-12-29|1999-12-07|Johnson & Johnson Professional, Inc.|Hip stem cement spacer|
    US6251092B1|1997-12-30|2001-06-26|Medtronic, Inc.|Deflectable guiding catheter|
    US5928239A|1998-03-16|1999-07-27|University Of Washington|Percutaneous surgical cavitation device and method|
    EP1063931A2|1998-03-19|2001-01-03|Oratec Interventions, Inc.|Catheter for delivery of energy to a surgical site|
    WO1999049819A1|1998-04-01|1999-10-07|Parallax Medical, Inc.|Pressure applicator for hard tissue implant placement|
    US7572263B2|1998-04-01|2009-08-11|Arthrocare Corporation|High pressure applicator|
    US6440138B1|1998-04-06|2002-08-27|Kyphon Inc.|Structures and methods for creating cavities in interior body regions|
    JP3360810B2|1998-04-14|2003-01-07|ペンタックス株式会社|Method for producing bone replacement material|
    US6106539A|1998-04-15|2000-08-22|Neosurg Technologies|Trocar with removable, replaceable tip|
    US6064902A|1998-04-16|2000-05-16|C.R. Bard, Inc.|Pulmonary vein ablation catheter|
    US6019765A|1998-05-06|2000-02-01|Johnson & Johnson Professional, Inc.|Morsellized bone allograft applicator device|
    US6059739A|1998-05-29|2000-05-09|Medtronic, Inc.|Method and apparatus for deflecting a catheter or lead|
    WO1999062416A1|1998-06-01|1999-12-09|Kyphon Inc.|Expandable preformed structures for deployment in interior body regions|
    US20020077595A1|1998-06-15|2002-06-20|Ronald R Hundertmark|Endovascular coronary sinus catheter and method of use|
    US6409722B1|1998-07-07|2002-06-25|Medtronic, Inc.|Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue|
    US6706039B2|1998-07-07|2004-03-16|Medtronic, Inc.|Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue|
    US6716216B1|1998-08-14|2004-04-06|Kyphon Inc.|Systems and methods for treating vertebral bodies|
    US6241734B1|1998-08-14|2001-06-05|Kyphon, Inc.|Systems and methods for placing materials into bone|
    US6123702A|1998-09-10|2000-09-26|Scimed Life Systems, Inc.|Systems and methods for controlling power in an electrosurgical probe|
    GB9820369D0|1998-09-19|1998-11-11|Giltech Ltd|Material|
    US6544215B1|1998-10-02|2003-04-08|Scimed Life Systems, Inc.|Steerable device for introducing diagnostic and therapeutic apparatus into the body|
    DE69920178T2|1998-12-09|2005-09-22|Cook Inc., Bloomington|SUPER-ELASTIC CURVED CAVITY NEEDLE FOR MEDICAL USE|
    IL128261D0|1999-01-27|1999-11-30|Disc O Tech Medical Tech Ltd|Expandable element|
    CA2360938C|1999-02-02|2008-01-08|Warren Oliver Haggard|Controlled release composite|
    AU770196B2|1999-02-04|2004-02-12|Warsaw Orthopedic, Inc.|Osteogenic paste compositions and uses thereof|
    US6203507B1|1999-03-03|2001-03-20|Cordis Webster, Inc.|Deflectable catheter with ergonomic handle|
    US6770079B2|1999-03-16|2004-08-03|American Osteomedix, Inc.|Apparatus and method for fixation of osteoporotic bone|
    US6395007B1|1999-03-16|2002-05-28|American Osteomedix, Inc.|Apparatus and method for fixation of osteoporotic bone|
    US6183435B1|1999-03-22|2001-02-06|Cordis Webster, Inc.|Multi-directional steerable catheters and control handles|
    AU6168699A|1999-03-24|2000-10-09|Parallax Medical, Inc.|Non-compliant system for delivery of implant material|
    US6506217B1|1999-03-29|2003-01-14|Arnett Facial Reconstruction Courses, Inc.|Moldable post-implantation bone filler and method|
    US6689823B1|1999-03-31|2004-02-10|The Brigham And Women's Hospital, Inc.|Nanocomposite surgical materials and method of producing them|
    US20040044350A1|1999-04-09|2004-03-04|Evalve, Inc.|Steerable access sheath and methods of use|
    US6270476B1|1999-04-23|2001-08-07|Cryocath Technologies, Inc.|Catheter|
    US6352533B1|1999-05-03|2002-03-05|Alan G. Ellman|Electrosurgical handpiece for treating tissue|
    US6582446B1|1999-05-06|2003-06-24|J. Alexander Marchosky|Method and apparatus for percutaneous osteoplasty|
    US6478793B1|1999-06-11|2002-11-12|Sherwood Services Ag|Ablation treatment of bone metastases|
    US6890329B2|1999-06-15|2005-05-10|Cryocath Technologies Inc.|Defined deflection structure|
    US6479565B1|1999-08-16|2002-11-12|Harold R. Stanley|Bioactive ceramic cement|
    US6783515B1|1999-09-30|2004-08-31|Arthrocare Corporation|High pressure delivery system|
    JP4454078B2|1999-10-08|2010-04-21|株式会社町田製作所|Endoscope bending tube and method of manufacturing the same|
    US7081122B1|1999-10-19|2006-07-25|Kyphon Inc.|Hand-held instruments that access interior body regions|
    US6575919B1|1999-10-19|2003-06-10|Kyphon Inc.|Hand-held instruments that access interior body regions|
    US20040087936A1|2000-11-16|2004-05-06|Barrx, Inc.|System and method for treating abnormal tissue in an organ having a layered tissue structure|
    US6241710B1|1999-12-20|2001-06-05|Tricardia Llc|Hypodermic needle with weeping tip and method of use|
    US6599961B1|2000-02-01|2003-07-29|University Of Kentucky Research Foundation|Polymethylmethacrylate augmented with carbon nanotubes|
    US6383188B2|2000-02-15|2002-05-07|The Spineology Group Llc|Expandable reamer|
    US6790210B1|2000-02-16|2004-09-14|Trans1, Inc.|Methods and apparatus for forming curved axial bores through spinal vertebrae|
    US7641657B2|2003-06-10|2010-01-05|Trans1, Inc.|Method and apparatus for providing posterior or anterior trans-sacral access to spinal vertebrae|
    US6740093B2|2000-02-28|2004-05-25|Stephen Hochschuler|Method and apparatus for treating a vertebral body|
    US6447514B1|2000-03-07|2002-09-10|Zimmer|Polymer filled hip fracture fixation device|
    US6332894B1|2000-03-07|2001-12-25|Zimmer, Inc.|Polymer filled spinal fusion cage|
    US6358251B1|2000-03-21|2002-03-19|University Of Washington|Method and apparatus for forming a cavity in soft tissue or bone|
    EP1272117A2|2000-03-31|2003-01-08|Rita Medical Systems, Inc.|Tissue biopsy and treatment apparatus and method|
    US6565588B1|2000-04-05|2003-05-20|Pathway Medical Technologies, Inc.|Intralumenal material removal using an expandable cutting device|
    AT318559T|2000-04-05|2006-03-15|Kyphon Inc|DEVICES FOR THE TREATMENT OF BROKEN AND / OR DISEASED BONE|
    JP3798983B2|2000-04-05|2006-07-19|パスウェイメディカルテクノロジーズインコーポレイテッド|System for removing obstructive substances transluminally|
    KR20070108267A|2000-04-07|2007-11-08|키폰 인크.|Insertion devices and method of use|
    US6638268B2|2000-04-07|2003-10-28|Imran K. Niazi|Catheter to cannulate the coronary sinus|
    US7815649B2|2000-04-07|2010-10-19|Kyphon SÀRL|Insertion devices and method of use|
    US6979312B2|2001-04-12|2005-12-27|Biotran Corporation, Inc.|Steerable sheath catheters|
    US6869445B1|2000-05-04|2005-03-22|Phillips Plastics Corp.|Packable ceramic beads for bone repair|
    US6743239B1|2000-05-25|2004-06-01|St. Jude Medical, Inc.|Devices with a bendable tip for medical procedures|
    DE60114832T2|2000-06-23|2006-07-20|Cryocath Technologies Inc., Kirkland|DEVICE FOR CYCLING|
    JP2004500963A|2000-06-27|2004-01-15|カイフォン　インコーポレイテッド|System and method for injecting flowable material into bone|
    GB0016516D0|2000-07-06|2000-08-23|Owen Mumford Ltd|Improvements relating to needle protection devices|
    FR2811538B1|2000-07-12|2003-02-07|Spine Next Sa|INTERVERTEBRAL CUTTING TOOL|
    CN1251651C|2000-07-14|2006-04-19|科丰公司|Systems and methods for treating vertebral bodies|
    DE60141653D1|2000-07-21|2010-05-06|Spineology Group Llc|A STRONG, POROUS NET BAG DEVICE AND ITS USE IN BONE SURGERY|
    JP4883874B2|2000-08-11|2012-02-22|ウォーソー・オーソペディック・インコーポレーテッド|Surgical instruments and methods for treating the spinal column|
    US7114501B2|2000-08-14|2006-10-03|Spine Wave, Inc.|Transverse cavity device and method|
    US6669692B1|2000-08-21|2003-12-30|Biosense Webster, Inc.|Ablation catheter with cooled linear electrode|
    US6679886B2|2000-09-01|2004-01-20|Synthes |Tools and methods for creating cavities in bone|
    EP1335887A4|2000-10-16|2004-06-23|Univ South Carolina|Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement|
    US20020068929A1|2000-10-24|2002-06-06|Roni Zvuloni|Apparatus and method for compressing a gas, and cryosurgery system and method utilizing same|
    AT448742T|2000-10-25|2009-12-15|Kyphon Inc|SYSTEMS FOR THE REPOSITION OF BROKEN BONE BY MEANS OF A CANNULA FOR THE REPONATION OF BONE FRACTURES|
    US6916306B1|2000-11-10|2005-07-12|Boston Scientific Scimed, Inc.|Steerable loop structures for supporting diagnostic and therapeutic elements in contact with body tissue|
    US6576249B1|2000-11-13|2003-06-10|El Gendler|Bone putty and method|
    US6511471B2|2000-12-22|2003-01-28|Biocardia, Inc.|Drug delivery catheters that attach to tissue and methods for their use|
    WO2002054941A2|2001-01-11|2002-07-18|Rita Medical Systems Inc|Bone-treatment instrument and method|
    GB0102529D0|2001-01-31|2001-03-21|Thales Optronics Staines Ltd|Improvements relating to thermal imaging cameras|
    US7008433B2|2001-02-15|2006-03-07|Depuy Acromed, Inc.|Vertebroplasty injection device|
    US6648880B2|2001-02-16|2003-11-18|Cryocath Technologies Inc.|Method of using cryotreatment to treat brain tissue|
    US7544196B2|2001-02-20|2009-06-09|Orthovita, Inc.|System and kit for delivery of restorative materials|
    US6375659B1|2001-02-20|2002-04-23|Vita Licensing, Inc.|Method for delivery of biocompatible material|
    DE10108261B4|2001-02-21|2006-07-20|Ivoclar Vivadent Ag|Polymerizable composition with particulate composite based filler|
    CN1162187C|2001-02-22|2004-08-18|华东理工大学|Inorganic bane adhesive and its application in body's hard tissue repair|
    US20020115742A1|2001-02-22|2002-08-22|Trieu Hai H.|Bioactive nanocomposites and methods for their use|
    US6623448B2|2001-03-30|2003-09-23|Advanced Cardiovascular Systems, Inc.|Steerable drug delivery device|
    US6575978B2|2001-04-05|2003-06-10|Spineology, Inc.|Circumferential resecting reamer tool|
    US6837867B2|2001-04-30|2005-01-04|Biosense Webster, Inc.|Steerable catheter with reinforced tip|
    US6610058B2|2001-05-02|2003-08-26|Cardiac Pacemakers, Inc.|Dual-profile steerable catheter|
    CN100518685C|2001-05-10|2009-07-29|脉管动力股份有限公司|RF tissue ablation apparatus and method|
    US6484904B1|2001-05-21|2002-11-26|Tah Industries, Inc.|Two-component cartridge system|
    ITVI20010126A1|2001-05-30|2002-11-30|Tecres Spa|RADIOPACO BONE CEMENT FOR ORTHOPEDIC USE AND METHOD OF REALIZATION|
    US6746451B2|2001-06-01|2004-06-08|Lance M. Middleton|Tissue cavitation device and method|
    US20020188300A1|2001-06-06|2002-12-12|Arramon Yves P.|Cannula system for hard tissue implant delivery|
    DE10129842C1|2001-06-15|2003-04-24|Bam Bundesanstalt Matforschung|Process for the production of a bioactive bone cement and bone cement kit|
    US6814734B2|2001-06-18|2004-11-09|Sdgi Holdings, Inc,|Surgical instrumentation and method for forming a passage in bone having an enlarged cross-sectional portion|
    NL1018438C1|2001-07-02|2003-01-08|Baat Medical Engineering B V|Foldable and foldable tools for placement in a spine.|
    US6835193B2|2001-07-10|2004-12-28|Myocardial Therapeutics, Inc.|Methods for controlled depth injections into interior body cavities|
    US6679906B2|2001-07-13|2004-01-20|Radiant Medical, Inc.|Catheter system with on-board temperature probe|
    US6620162B2|2001-07-20|2003-09-16|Spineology, Inc.|Device for inserting fill material particles into body cavities|
    WO2004110300A2|2001-07-25|2004-12-23|Disc Orthopaedic Technologies Inc.|Deformable tools and implants|
    WO2006011152A2|2004-06-17|2006-02-02|Disc-O-Tech Medical Technologies, Ltd.|Methods for treating bone and other tissue|
    JP4345478B2|2001-08-08|2009-10-14|株式会社カネカ|Dilatation catheter|
    JP3603278B2|2001-09-06|2004-12-22|理学電機工業株式会社|X-ray fluorescence analysis system and program used therefor|
    US20030050644A1|2001-09-11|2003-03-13|Boucher Ryan P.|Systems and methods for accessing and treating diseased or fractured bone employing a guide wire|
    US6893431B2|2001-10-15|2005-05-17|Scimed Life Systems, Inc.|Medical device for delivering patches|
    GB0124742D0|2001-10-16|2001-12-05|Biocomposites Ltd|Biodegradable materials|
    US20030032963A1|2001-10-24|2003-02-13|Kyphon Inc.|Devices and methods using an expandable body with internal restraint for compressing cancellous bone|
    US7004945B2|2001-11-01|2006-02-28|Spinewave, Inc.|Devices and methods for the restoration of a spinal disc|
    US6913594B2|2001-12-31|2005-07-05|Biosense Webster, Inc.|Dual-function catheter handle|
    WO2003061724A2|2002-01-16|2003-07-31|Eva Corporation|Catheter hand-piece apparatus and method of using the same|
    US6955716B2|2002-03-01|2005-10-18|American Dental Association Foundation|Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates|
    US8882755B2|2002-03-05|2014-11-11|Kimberly-Clark Inc.|Electrosurgical device for treatment of tissue|
    US6896675B2|2002-03-05|2005-05-24|Baylis Medical Company Inc.|Intradiscal lesioning device|
    US7294127B2|2002-03-05|2007-11-13|Baylis Medical Company Inc.|Electrosurgical tissue treatment method|
    US8518036B2|2002-03-05|2013-08-27|Kimberly-Clark Inc.|Electrosurgical tissue treatment method|
    SE0201052D0|2002-04-04|2002-04-04|Cerbio Tech Ab|Biocompatible cement compositions and method of manufacturing|
    EP1782845B1|2002-05-29|2008-12-17|Heraeus Kulzer GmbH|Bone cement and X-ray contrast agent and methods of manufacturing the same|
    US20030225432A1|2002-05-31|2003-12-04|Baptiste Reginald C.|Soft tissue retraction device for an endoscopic instrument|
    US7462181B2|2002-06-04|2008-12-09|Stanford Office Of Technology Licensing|Device and method for rapid aspiration and collection of body tissue from within an enclosed body space|
    US7166133B2|2002-06-13|2007-01-23|Kensey Nash Corporation|Devices and methods for treating defects in the tissue of a living being|
    US7029468B2|2002-06-25|2006-04-18|Enpath Medical, Inc.|Catheter assembly with side wall exit lumen and method therefor|
    US6730095B2|2002-06-26|2004-05-04|Scimed Life Systems, Inc.|Retrograde plunger delivery system|
    KR100465985B1|2002-07-30|2005-01-15|재단법인서울대학교산학협력재단|Bioactive Biphasic Ceramic Compositions for Artificial Bone and Method for Making the Same|
    US20040023384A1|2002-07-31|2004-02-05|Isis Pharmaceuticals Inc.|Antisense modulation of G protein-coupled receptor 12 expression|
    US7901407B2|2002-08-02|2011-03-08|Boston Scientific Scimed, Inc.|Media delivery device for bone structures|
    US7393350B2|2002-08-06|2008-07-01|Erbe Elektromedizin Gmbh|Cryo-surgical apparatus and methods|
    US20040087994A1|2002-08-29|2004-05-06|Loubert Suddaby|Mechanical bone tamping device for repair of osteoporotic bone fractures|
    US7138442B2|2002-08-30|2006-11-21|Biomet, Inc.|Reduced exothermic bone replacement cement|
    US8808284B2|2008-09-26|2014-08-19|Relievant Medsystems, Inc.|Systems for navigating an instrument through bone|
    US6907884B2|2002-09-30|2005-06-21|Depay Acromed, Inc.|Method of straddling an intraosseous nerve|
    US8361067B2|2002-09-30|2013-01-29|Relievant Medsystems, Inc.|Methods of therapeutically heating a vertebral body to treat back pain|
    US8613744B2|2002-09-30|2013-12-24|Relievant Medsystems, Inc.|Systems and methods for navigating an instrument through bone|
    US7066942B2|2002-10-03|2006-06-27|Wright Medical Technology, Inc.|Bendable needle for delivering bone graft material and method of use|
    US7918819B2|2002-11-15|2011-04-05|Health & Human Services - NIH|Variable curve catheter|
    US7582309B2|2002-11-15|2009-09-01|Etex Corporation|Cohesive demineralized bone compositions|
    US6979352B2|2002-11-21|2005-12-27|Depuy Acromed|Methods of performing embolism-free vertebroplasty and devices therefor|
    US6945956B2|2002-12-23|2005-09-20|Medtronic, Inc.|Steerable catheter|
    US20060024348A1|2002-12-31|2006-02-02|Doxa Aktiebolag|Chemically bonded biomaterial element with tailored properties|
    SE524494C2|2002-12-31|2004-08-17|Doxa Ab|Chemically bonded biomaterial elements with tailored properties|
    US7390298B2|2003-01-06|2008-06-24|City Of Hope|Expandable surgical retractor for internal body spaces approached with minimally invasive incisions or through existing orifices|
    US20040158237A1|2003-02-11|2004-08-12|Marwan Abboud|Multi-energy ablation station|
    JP2006513760A|2003-02-13|2006-04-27|ジンテーズ　アクチエンゲゼルシャフト　クール|Injectable bone replacement compound|
    WO2004073563A2|2003-02-14|2004-09-02|Depuy Spine, Inc.|In-situ formed intervertebral fusion device|
    JP2004242936A|2003-02-14|2004-09-02|Terumo Corp|Puncture needle|
    US6875219B2|2003-02-14|2005-04-05|Yves P. Arramon|Bone access system|
    US20060064101A1|2004-02-12|2006-03-23|Arthrocare Corporation|Bone access system|
    GB0307834D0|2003-04-04|2003-05-14|Ta Contrast Ab|Composition|
    US20060206116A1|2003-05-07|2006-09-14|Yeung Jeffrey E|Injection device for the invertebral disc|
    US7625364B2|2003-05-27|2009-12-01|Cardia, Inc.|Flexible center connection for occlusion device|
    JP4727232B2|2003-06-06|2011-07-20|株式会社半導体エネルギー研究所|Semiconductor device|
    US7112205B2|2003-06-17|2006-09-26|Boston Scientific Scimed, Inc.|Apparatus and methods for delivering compounds into vertebrae for vertebroplasty|
    US8415407B2|2004-03-21|2013-04-09|Depuy Spine, Inc.|Methods, materials, and apparatus for treating bone and other tissue|
    CA2533020A1|2003-07-18|2005-03-03|Ev3 Santa Rosa, Inc.|Remotely activated mitral annuloplasty system and methods|
    US7887557B2|2003-08-14|2011-02-15|Boston Scientific Scimed, Inc.|Catheter having a cutting balloon including multiple cavities or multiple channels|
    WO2005023085A2|2003-09-03|2005-03-17|Kyphon Inc.|Devices for creating voids in interior body regions and related methods|
    US7824412B2|2003-09-05|2010-11-02|Medical Design Instruments LLC|Cement/biologics inserter and method for bone-fastener fixation augmentation|
    US7156843B2|2003-09-08|2007-01-02|Medtronic, Inc.|Irrigated focal ablation tip|
    US8579908B2|2003-09-26|2013-11-12|DePuy Synthes Products, LLC.|Device for delivering viscous material|
    US7909833B2|2003-09-29|2011-03-22|Depuy Acromed, Inc.|Vertebroplasty device having a flexible plunger|
    US7094202B2|2003-09-29|2006-08-22|Ethicon Endo-Surgery, Inc.|Method of operating an endoscopic device with one hand|
    US7998112B2|2003-09-30|2011-08-16|Abbott Cardiovascular Systems Inc.|Deflectable catheter assembly and method of making same|
    US7708733B2|2003-10-20|2010-05-04|Arthrocare Corporation|Electrosurgical method and apparatus for removing tissue within a bone body|
    DE50304905D1|2003-11-18|2006-10-12|Somatex Medical Technologies Gmbh|INJECTION PUMP|
    US20050113836A1|2003-11-25|2005-05-26|Lozier Antony J.|Expandable reamer|
    WO2005053581A1|2003-12-01|2005-06-16|Broockeville Corporation N.V.|A tow-component mixing and dispensing device|
    US8221424B2|2004-12-20|2012-07-17|Spinascope, Inc.|Surgical instrument for orthopedic surgery|
    US7727232B1|2004-02-04|2010-06-01|Salient Surgical Technologies, Inc.|Fluid-assisted medical devices and methods|
    US7351280B2|2004-02-10|2008-04-01|New York University|Macroporous, resorbable and injectible calcium phosphate-based cements for bone repair, augmentation, regeneration, and osteoporosis treatment|
    US7488322B2|2004-02-11|2009-02-10|Medtronic, Inc.|High speed surgical cutting instrument|
    US7641664B2|2004-02-12|2010-01-05|Warsaw Orthopedic, Inc.|Surgical instrumentation and method for treatment of a spinal structure|
    US20050187556A1|2004-02-25|2005-08-25|Synecor, Llc|Universal percutaneous spinal access system|
    US7407893B2|2004-03-05|2008-08-05|Applied Materials, Inc.|Liquid precursors for the CVD deposition of amorphous carbon films|
    US7959634B2|2004-03-29|2011-06-14|Soteira Inc.|Orthopedic surgery access devices|
    US7507241B2|2004-04-05|2009-03-24|Expanding Orthopedics Inc.|Expandable bone device|
    US7465318B2|2004-04-15|2008-12-16|Soteira, Inc.|Cement-directing orthopedic implants|
    US7452351B2|2004-04-16|2008-11-18|Kyphon Sarl|Spinal diagnostic methods and apparatus|
    US9554691B2|2004-04-21|2017-01-31|Acclarent, Inc.|Endoscopic methods and devices for transnasal procedures|
    US20050251267A1|2004-05-04|2005-11-10|John Winterbottom|Cell permeable structural implant|
    US8163030B2|2004-05-06|2012-04-24|Degradable Solutions Ag|Biocompatible bone implant compositions and methods for repairing a bone defect|
    EP1748739A1|2004-05-19|2007-02-07|Sintea Biotech S.p.A.|Intravertebral widening device, injection device , and kit and method for kyphoplasty|
    WO2005122938A1|2004-06-10|2005-12-29|Arthrocare Corporation|Electrosurgical method and apparatus for removing tissue within a bone body|
    CA2570798A1|2004-06-16|2006-01-05|Warsaw Orthopedic, Inc.|Surgical instrumentation for the repair of vertebral bodies|
    US20050283148A1|2004-06-17|2005-12-22|Janssen William M|Ablation apparatus and system to limit nerve conduction|
    US20060085009A1|2004-08-09|2006-04-20|Csaba Truckai|Implants and methods for treating bone|
    US7503920B2|2004-08-11|2009-03-17|Tzony Siegal|Spinal surgery system and method|
    US20080319445A9|2004-08-17|2008-12-25|Scimed Life Systems, Inc.|Apparatus and methods for delivering compounds into vertebrae for vertebroplasty|
    US20060106459A1|2004-08-30|2006-05-18|Csaba Truckai|Bone treatment systems and methods|
    US7396360B2|2004-09-29|2008-07-08|The Cleveland Clinic Foundation|Minimally invasive method and apparatus for fusing adjacent vertebrae|
    US7682378B2|2004-11-10|2010-03-23|Dfine, Inc.|Bone treatment systems and methods for introducing an abrading structure to abrade bone|
    US20060100706A1|2004-11-10|2006-05-11|Shadduck John H|Stent systems and methods for spine treatment|
    US8663225B2|2004-11-12|2014-03-04|Medtronic, Inc.|Hydrogel bone void filler|
    US8562607B2|2004-11-19|2013-10-22|Dfine, Inc.|Bone treatment systems and methods|
    US7559932B2|2004-12-06|2009-07-14|Dfine, Inc.|Bone treatment systems and methods|
    US8583260B2|2004-12-28|2013-11-12|St. Jude Medical, Atrial Fibrillation Division, Inc.|Long travel steerable catheter actuator|
    DE102005025946A1|2005-01-26|2006-08-03|Erbe Elektromedizin Gmbh|High frequency surgical device for treating monopolar coagulation of biological tissue, has control unit controlling generator to supply voltage to target region and producing switching off signal if target input reaches final value|
    GB0502384D0|2005-02-04|2005-03-16|Instrumedical Ltd|Electro-surgical needle apparatus|
    US20060184192A1|2005-02-11|2006-08-17|Markworth Aaron D|Systems and methods for providing cavities in interior body regions|
    US7959601B2|2005-02-14|2011-06-14|Biosense Webster, Inc.|Steerable catheter with in-plane deflection|
    US20060200121A1|2005-03-03|2006-09-07|Mowery Thomas M|Navigable, multi-positional and variable tissue ablation apparatus and methods|
    JP2006263184A|2005-03-24|2006-10-05|Gc Corp|Bone cement injection and filling method and leakage prevention bag for injecting and filling bone cement|
    US7497853B2|2005-05-05|2009-03-03|Enpath Medical Inc.|Deflectable catheter steering and locking system|
    US20070016130A1|2005-05-06|2007-01-18|Leeflang Stephen A|Complex Shaped Steerable Catheters and Methods for Making and Using Them|
    US7442190B2|2005-05-13|2008-10-28|Cryocath Technologies Inc.|Contact assessment of balloon catheters|
    US8187327B2|2005-05-18|2012-05-29|Kyphon Sarl|Selectively-expandable bone scaffold|
    WO2006127904A1|2005-05-24|2006-11-30|Gary Botimer|Expandable surgical reaming tool|
    US20060276797A1|2005-05-24|2006-12-07|Gary Botimer|Expandable reaming device|
    EP1922006A2|2005-05-26|2008-05-21|Smith & Nephew, Inc.|Electrothermal intervertebral disc treatment|
    US20060293687A1|2005-06-07|2006-12-28|Bogert Roy B|Syringe plunger seal|
    US20070010845A1|2005-07-08|2007-01-11|Gorman Gong|Directionally controlled expandable device and methods for use|
    WO2007008667A2|2005-07-11|2007-01-18|Kyphon, Inc.|Systems and methods for providing cavities in interior body regions|
    US20070006692A1|2005-07-11|2007-01-11|Phan Christopher U|Torque limiting device|
    US8021366B2|2005-07-11|2011-09-20|Kyphon Sarl|Axial load limiting system and methods|
    US7794458B2|2005-07-22|2010-09-14|Boston Scientific Scimed, Inc.|Bipolar radio frequency ablation device with retractable insulator|
    JP4944111B2|2005-08-16|2012-05-30|ベンベニューメディカル，インコーポレイテッド|Spinal distractor|
    CN2841051Y|2005-08-24|2006-11-29|汤枧根|The umbrella shape therapeutic electrode|
    US20070067034A1|2005-08-31|2007-03-22|Chirico Paul E|Implantable devices and methods for treating micro-architecture deterioration of bone tissue|
    US20070162043A1|2005-09-01|2007-07-12|Csaba Truckai|Methods for sensing retrograde flows of bone fill material|
    US7754246B2|2005-09-09|2010-07-13|Wright Medical Technology, Inc.|Composite bone graft substitute cement and articles produced therefrom|
    US20070093840A1|2005-10-06|2007-04-26|Pacelli Nicolas J|Flexible shaft|
    EP1945298B1|2005-11-09|2013-04-17|Korea University Industrial & Academic Collaboration Foundation|Radio frequency ablation electrode for selected tissue removal|
    US7823753B2|2005-11-18|2010-11-02|Kovac Karen S|Double barrel caulking gun caddy|
    US7713273B2|2005-11-18|2010-05-11|Carefusion 2200, Inc.|Device, system and method for delivering a curable material into bone|
    US7799035B2|2005-11-18|2010-09-21|Carefusion 2200, Inc.|Device, system and method for delivering a curable material into bone|
    WO2007078692A2|2005-12-23|2007-07-12|The Board Of Trustees Of The Leland Stanford Junior University|Systems and methods for fixation of bone with an expandable device|
    US7993334B2|2005-12-29|2011-08-09|Boston Scientific Scimed, Inc.|Low-profile, expanding single needle ablation probe|
    EP1976478A4|2006-01-23|2009-09-16|Osseon Therapeutics Inc|Bone cement composite containing particles in a non-uniform spatial distribution and devices for implementation|
    US9301792B2|2006-01-27|2016-04-05|Stryker Corporation|Low pressure delivery system and method for delivering a solid and liquid mixture into a target site for medical treatment|
    US20070203500A1|2006-02-28|2007-08-30|Vermillion Technologies, Llc|Apparatus and method of shaping an intervertebral space|
    US7976542B1|2006-03-02|2011-07-12|Cosman Eric R|Adjustable high frequency electrode|
    US20070270876A1|2006-04-07|2007-11-22|Yi-Chen Kuo|Vertebra bone cement introduction system|
    FR2899967B1|2006-04-12|2008-06-20|Valeo Vision Sa|METHOD FOR DETERMINING THE ANGULAR POSITION OF A PROJECTOR USING MULTIPLE MEANS FOR MEASURING A MAGNETIC FIELD|
    US7905884B2|2006-04-27|2011-03-15|Warsaw Orthopedic, Inc.|Method for use of dilating stylet and cannula|
    US7615044B2|2006-05-03|2009-11-10|Greatbatch Ltd.|Deflectable sheath handle assembly and method therefor|
    US8075556B2|2006-05-23|2011-12-13|Andres Betts|High frequency epidural neuromodulation catheter for effectuating RF treatment in spinal canal and method of using same|
    US20080033422A1|2006-08-04|2008-02-07|Turner Paul F|Microwave applicator with margin temperature sensing element|
    US20080058840A1|2006-09-01|2008-03-06|Albrecht Thomas E|Implantable coil for insertion into a hollow body organ|
    US20080086142A1|2006-10-06|2008-04-10|Kohm Andrew C|Products and Methods for Delivery of Material to Bone and Other Internal Body Parts|
    US7909873B2|2006-12-15|2011-03-22|Soteira, Inc.|Delivery apparatus and methods for vertebrostenting|
    WO2008084479A2|2007-01-09|2008-07-17|Nonlinear Technologies Ltd.|Devices for forming curved or closed-loop structures|
    US20080183265A1|2007-01-30|2008-07-31|Cardiac Pacemakers, Inc.|Transvascular lead with proximal force relief|
    US8211099B2|2007-01-31|2012-07-03|Tyco Healthcare Group Lp|Thermal feedback systems and methods of using the same|
    US8157804B2|2007-03-07|2012-04-17|Vertech, Inc.|Expandable blade device for stabilizing long bone fractures|
    WO2008124533A1|2007-04-03|2008-10-16|Dfine, Inc.|Bone treatment systems and methods|
    US20080269766A1|2007-04-30|2008-10-30|Warsaw Orthopedic, Inc.|Intravertebral reduction device with retention balls|
    US8465420B2|2007-05-18|2013-06-18|Boston Scientific Scimed, Inc.|Articulating torqueable hollow device|
    CA2692002A1|2007-05-21|2008-11-27|Aoi Medical Inc.|Articulating cavitation device|
    JP5400784B2|2007-10-09|2014-01-29|ボストンサイエンティフィックリミテッド|Electrophysiological electrode and device comprising electrophysiological electrode|
    US20090105775A1|2007-10-19|2009-04-23|David Mitchell|Cannula with lateral access and directional exit port|
    US20090131867A1|2007-11-16|2009-05-21|Liu Y King|Steerable vertebroplasty system with cavity creation element|
    US20090131950A1|2007-11-16|2009-05-21|Liu Y King|Vertebroplasty method with enhanced control|
    US20090299282A1|2007-11-16|2009-12-03|Osseon Therapeutics, Inc.|Steerable vertebroplasty system with a plurality of cavity creation elements|
    US20090131886A1|2007-11-16|2009-05-21|Liu Y King|Steerable vertebroplasty system|
    US9510885B2|2007-11-16|2016-12-06|Osseon Llc|Steerable and curvable cavity creation system|
    WO2010135602A1|2009-05-20|2010-11-25|Osseon Therapeutics, Inc.|Steerable curvable ablation catheter for vertebroplasty|
    US8961571B2|2007-11-19|2015-02-24|David Lee|Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants|
    US20090182427A1|2007-12-06|2009-07-16|Osseon Therapeutics, Inc.|Vertebroplasty implant with enhanced interfacial shear strength|
    US8353902B2|2008-01-31|2013-01-15|Vivant Medical, Inc.|Articulating ablation device and method|
    US20090198243A1|2008-02-06|2009-08-06|Melsheimer Jeffry S|Device and method for stabilizing a damaged bone with a bone cement mixture|
    US8262672B2|2008-04-16|2012-09-11|Medtronic, Inc.|Medical delivery device construction|
    US7762164B2|2008-06-02|2010-07-27|Eca Medical Instruments|Torque-limiting device|
    ES2554169T3|2008-07-15|2015-12-16|Thomas Steffen|Bone Cement Injection Device|
    US8246627B2|2008-08-07|2012-08-21|Stryker Corporation|Cement delivery device for introducing cement into tissue, the device having a cavity creator|
    US9101734B2|2008-09-09|2015-08-11|Biosense Webster, Inc.|Force-sensing catheter with bonded center strut|
    EP2364128A4|2008-09-30|2013-07-24|Dfine Inc|System for use in treatment of vertebral fractures|
    US8758349B2|2008-10-13|2014-06-24|Dfine, Inc.|Systems for treating a vertebral body|
    US20100114184A1|2008-10-07|2010-05-06|Brainsgate Ltd.|Flexible tools for preparing bony canals|
    US8355799B2|2008-12-12|2013-01-15|Arthrocare Corporation|Systems and methods for limiting joint temperature|
    JP2012515024A|2009-01-15|2012-07-05|キャスリックスリミテッド|Steerable stylet|
    US8696695B2|2009-04-28|2014-04-15|Avinger, Inc.|Guidewire positioning catheter|
    US20100298832A1|2009-05-20|2010-11-25|Osseon Therapeutics, Inc.|Steerable curvable vertebroplasty drill|
    US8057403B2|2009-05-29|2011-11-15|Promex Technologies, Inc.|Flexible biopsy needle|
    WO2011066465A1|2009-11-25|2011-06-03|Osseon Therapeutics, Inc.|Steerable and curvable vertebroplasty system with clog-resistant exit ports|
    US9616246B2|2010-01-04|2017-04-11|Covidien Lp|Apparatus and methods for treating hollow anatomical structures|
    US8465488B2|2010-03-16|2013-06-18|Olympus Medical Systems Corporation|Endoscopic surgical instrument|
    US10058336B2|2010-04-08|2018-08-28|Dfine, Inc.|System for use in treatment of vertebral fractures|
    US9125671B2|2010-04-29|2015-09-08|Dfine, Inc.|System for use in treatment of vertebral fractures|
    US9526507B2|2010-04-29|2016-12-27|Dfine, Inc.|System for use in treatment of vertebral fractures|
    CN106108972B|2010-04-29|2019-08-02|Dfine有限公司|System for treating vertebral fracture|
    US9241762B2|2010-06-03|2016-01-26|Covidien Lp|Specific absorption rate measurement and energy-delivery device characterization using image analysis|
    WO2012071464A1|2010-11-22|2012-05-31|Dfine, Inc.|System for use in treatment of vertebral fractures|
    WO2012151396A2|2011-05-03|2012-11-08|Shifamed Holdings, Llc|Steerable delivery sheaths|
    US9119639B2|2011-08-09|2015-09-01|DePuy Synthes Products, Inc.|Articulated cavity creator|
    US20130072941A1|2011-09-16|2013-03-21|Francisca Tan-Malecki|Cement Injector and Cement Injector Connectors, and Bone Cement Injector Assembly|
    US20130237795A1|2012-03-09|2013-09-12|Carefusion 2200, Inc.|Performance concentric electromyography needle|
    EP2830523B1|2012-03-27|2021-12-22|Dfine, Inc.|Systems for use in controlling tissue ablation volume by temperature monitoring|
    JP6195625B2|2012-11-05|2017-09-13|リリーバント メドシステムズ、インコーポレイテッド|System and method for creating a curved pathway through bone and regulating nerves within the bone|
    US9918766B2|2012-12-12|2018-03-20|Dfine, Inc.|Devices, methods and systems for affixing an access device to a vertebral body for the insertion of bone cement|
    CA2927436A1|2013-10-15|2015-04-23|Stryker Corporation|Device for creating a void space in living tissue, the device including a handle with a control knob that can be set regardless of the orientation of the handle|
    EP3397334A4|2015-10-06|2019-08-07|Halcyon Medical, Inc.|Aorticorenal ganglion detection|US6907884B2|2002-09-30|2005-06-21|Depay Acromed, Inc.|Method of straddling an intraosseous nerve|
    US8361067B2|2002-09-30|2013-01-29|Relievant Medsystems, Inc.|Methods of therapeutically heating a vertebral body to treat back pain|
    US10588691B2|2012-09-12|2020-03-17|Relievant Medsystems, Inc.|Radiofrequency ablation of tissue within a vertebral body|
    US10028753B2|2008-09-26|2018-07-24|Relievant Medsystems, Inc.|Spine treatment kits|
    US7258690B2|2003-03-28|2007-08-21|Relievant Medsystems, Inc.|Windowed thermal ablation probe|
    WO2010036865A2|2008-09-26|2010-04-01|Relievant Medsystems, Inc.|Systems and methods for navigating an instrument through bone|
    US8758349B2|2008-10-13|2014-06-24|Dfine, Inc.|Systems for treating a vertebral body|
    EP2364128A4|2008-09-30|2013-07-24|Dfine Inc|System for use in treatment of vertebral fractures|
    US20100298832A1|2009-05-20|2010-11-25|Osseon Therapeutics, Inc.|Steerable curvable vertebroplasty drill|
    US10058336B2|2010-04-08|2018-08-28|Dfine, Inc.|System for use in treatment of vertebral fractures|
    CN106108972B|2010-04-29|2019-08-02|Dfine有限公司|System for treating vertebral fracture|
    US9526507B2|2010-04-29|2016-12-27|Dfine, Inc.|System for use in treatment of vertebral fractures|
    US9125671B2|2010-04-29|2015-09-08|Dfine, Inc.|System for use in treatment of vertebral fractures|
    WO2012071464A1|2010-11-22|2012-05-31|Dfine, Inc.|System for use in treatment of vertebral fractures|
    ES2600924T3|2011-01-31|2017-02-13|St. Jude Medical, Inc.|Adjustable prosthetic anatomical device support element and handle for implantation of an annuloplasty ring|
    EP3106130B1|2011-01-31|2018-09-05|St. Jude Medical, LLC|An adjustment tool for a prosthetic device|
    EP2670355B1|2011-01-31|2016-11-23|St. Jude Medical, Inc.|Tool for the adjustment of a prosthetic anatomical device|
    CN106420040B|2011-04-12|2020-08-28|热医学公司|Method and apparatus for heating fluid in fluid enhanced ablation therapy|
    WO2013101772A1|2011-12-30|2013-07-04|Relievant Medsystems, Inc.|Systems and methods for treating back pain|
    EP2830523B1|2012-03-27|2021-12-22|Dfine, Inc.|Systems for use in controlling tissue ablation volume by temperature monitoring|
    EP3120788B1|2012-06-20|2019-09-04|Stryker Corporation|System for off-axis tissue manipulation|
    US10022176B2|2012-08-15|2018-07-17|Thermedical, Inc.|Low profile fluid enhanced ablation therapy devices and methods|
    JP6195625B2|2012-11-05|2017-09-13|リリーバント メドシステムズ、インコーポレイテッド|System and method for creating a curved pathway through bone and regulating nerves within the bone|
    US9918766B2|2012-12-12|2018-03-20|Dfine, Inc.|Devices, methods and systems for affixing an access device to a vertebral body for the insertion of bone cement|
    US9717551B2|2013-02-21|2017-08-01|Carefusion 2200, Inc.|Intravertebral tissue ablation device and method|
    US9033972B2|2013-03-15|2015-05-19|Thermedical, Inc.|Methods and devices for fluid enhanced microwave ablation therapy|
    WO2014151273A1|2013-03-15|2014-09-25|Medtronic Ardian Luxembourg S.A.R.L.|Treatment device with electrode contact surface configured for enhancing uniformity of electrical energy distribution and associated devices and methods|
    US9610396B2|2013-03-15|2017-04-04|Thermedical, Inc.|Systems and methods for visualizing fluid enhanced ablation therapy|
    US10548663B2|2013-05-18|2020-02-04|Medtronic Ardian Luxembourg S.A.R.L.|Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods|
    US9724151B2|2013-08-08|2017-08-08|Relievant Medsystems, Inc.|Modulating nerves within bone using bone fasteners|
    CA2927436A1|2013-10-15|2015-04-23|Stryker Corporation|Device for creating a void space in living tissue, the device including a handle with a control knob that can be set regardless of the orientation of the handle|
    EP3122233B1|2014-03-28|2018-10-24|Spiration, Inc. D.B.A. Olympus Respiratory America|System for predictable deployment of a medical device|
    CN107106226B|2014-09-05|2019-09-24|埃派克斯医疗公司|Electrosurgery snare device|
    US9901392B2|2015-05-11|2018-02-27|Dfine, Inc.|System for use in treatment of vertebral fractures|
    JP6995041B2|2015-10-20|2022-01-14|ジャイラス エーシーエムアイ インク|Resection device|
    JP6892869B2|2016-02-26|2021-06-23|ニューロナノ アクチェボラグ|How to provide an implant site in soft tissue|
    US9743984B1|2016-08-11|2017-08-29|Thermedical, Inc.|Devices and methods for delivering fluid to tissue during ablation therapy|
    US10702289B2|2016-09-26|2020-07-07|Klsmc Instruments, Llc|Arthroscopic drill blade and arthroscopic drill access system made therefrom|
    US11207081B2|2016-10-21|2021-12-28|University Of Louisville Research Foundation, Inc.|Systems and methods for intramedullary preparations|
    CN109862834A|2016-10-27|2019-06-07|Dfine有限公司|Hinged osteotome with cement delivering channel|
    US11052237B2|2016-11-22|2021-07-06|Dfine, Inc.|Swivel hub|
    CA3041114A1|2016-11-28|2018-05-31|Dfine, Inc.|Tumor ablation devices and related methods|
    EP3551100B1|2016-12-09|2021-11-10|Dfine, Inc.|Medical devices for treating hard tissues|
    US10660656B2|2017-01-06|2020-05-26|Dfine, Inc.|Osteotome with a distal portion for simultaneous advancement and articulation|
    US11083871B2|2018-05-03|2021-08-10|Thermedical, Inc.|Selectively deployable catheter ablation devices|
    CN109199524B|2018-10-17|2020-04-24|郑州大学第一附属医院|Rib cutter under thoracoscope|
    WO2020219392A2|2019-04-24|2020-10-29|Stryker Corporation|Systems and methods for off-axis augmentation of a vertebral body|
    WO2021050767A1|2019-09-12|2021-03-18|Relievant Medsystems, Inc.|Systems and methods for tissue modulation|
    法律状态:
    2019-10-22| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-07-21| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law|
    2021-01-05| B09A| Decision: intention to grant|
    2021-03-09| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/04/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US32939410P| true| 2010-04-29|2010-04-29|
    US61/329,394|2010-04-29|
    PCT/US2011/034628|WO2011137377A1|2010-04-29|2011-04-29|System for use in treatment of vertebral fractures|
    [返回顶部]